About   Help   FAQ
Susd4 Gene Detail
Summary
  • Symbol
    Susd4
  • Name
    sushi domain containing 4
  • Synonyms
    E430021N18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138351
    NCBI Gene: 96935
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:182591609-182724161 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 85.94 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3859 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138351
 protein coding gene Chr1:182591425-182724161 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016898
 protein coding gene Chr1:189424452-189564245 (+)
A/J MGP_AJ_G0016877
 protein coding gene Chr1:181693717-181826824 (+)
AKR/J MGP_AKRJ_G0016842
 protein coding gene Chr1:187086349-187223951 (+)
BALB/cJ MGP_BALBcJ_G0016835
 protein coding gene Chr1:182329130-182463825 (+)
C3H/HeJ MGP_C3HHeJ_G0016659
 protein coding gene Chr1:187903297-188038448 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017298
 protein coding gene Chr1:195516005-195650351 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015005
 protein coding gene Chr1:172766875-172895637 (+)
CAST/EiJ MGP_CASTEiJ_G0016241
 protein coding gene Chr1:187256511-187397169 (+)
CBA/J MGP_CBAJ_G0016633
 protein coding gene Chr1:202773182-202926299 (+)
DBA/2J MGP_DBA2J_G0016739
 protein coding gene Chr1:180475011-180606628 (+)
FVB/NJ MGP_FVBNJ_G0016735
 protein coding gene Chr1:178602068-178738075 (+)
LP/J MGP_LPJ_G0016814
 protein coding gene Chr1:190616146-190751829 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016767
 protein coding gene Chr1:209767073-209905945 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017335
 protein coding gene Chr1:186920864-187058686 (+)
PWK/PhJ MGP_PWKPhJ_G0016029
 protein coding gene Chr1:179662178-179796390 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015805
 protein coding gene Chr1:185861301-186005665 (+)
WSB/EiJ MGP_WSBEiJ_G0016304
 protein coding gene Chr1:187101880-187236587 (+)



Homology
more
  • Human Ortholog
    SUSD4, sushi domain containing 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SUSD4, sushi domain containing 4
  • Synonyms
    PRO222
  • Links
    NCBI Gene ID: 55061
    neXtProt AC: NX_Q5VX71
    UniProt: Q5VX71

  • Chr Location
    1q41; chr1:223220819-223365235 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal hippocampal and cerebellar neuronal morphologies, anxiety-like behaviors, defects in motor performance, and increased protein levels of the complement component C1q in the brain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    7
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 96935 NCBI Gene Model | MGI Sequence Detail 132553 C57BL/6J ±  kb
    transcript NM_001356464 RefSeq | MGI Sequence Detail 3059 C57BL/6  
    polypeptide Q8BH32 UniProt | EBI | MGI Sequence Detail 490 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2138725
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 3
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:317347 Gonzalez-Calvo I, et al., Sushi domain-containing protein 4 controls synaptic plasticity and motor learning. Elife. 2021 Mar 4;10:e65712
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory