Tmem237 MGI Mouse Gene Detail - MGI:2138365

Symbol

Tmem237
Name

transmembrane protein 237
Synonyms

Als2cr4, LOC381259

Feature Type

protein coding gene
IDs

MGI:2138365
NCBI Gene: 381259
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:59139749-59159567 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 29.20 cM
Mapping Data

2 experiments

SNPs within 2kb

627 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2138365	protein coding gene	Chr1:59139743-59159567 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016062	protein coding gene	Chr1:59050432-59068669 (-)
A/J	MGP_AJ_G0016045	protein coding gene	Chr1:56995293-57014321 (-)
AKR/J	MGP_AKRJ_G0016001	protein coding gene	Chr1:58590090-58611147 (-)
BALB/cJ	MGP_BALBcJ_G0016000	protein coding gene	Chr1:57037553-57057133 (-)
C3H/HeJ	MGP_C3HHeJ_G0015832	protein coding gene	Chr1:58839401-58858048 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016453	protein coding gene	Chr1:61373877-61402578 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014174	protein coding gene	Chr1:52821582-52838267 (-)
CAST/EiJ	MGP_CASTEiJ_G0015414	protein coding gene	Chr1:57977925-57995968 (-)
CBA/J	MGP_CBAJ_G0015804	protein coding gene	Chr1:63295842-63317685 (-)
DBA/2J	MGP_DBA2J_G0015905	protein coding gene	Chr1:56420528-56439476 (-)
FVB/NJ	MGP_FVBNJ_G0015907	protein coding gene	Chr1:55723736-55743069 (-)
LP/J	MGP_LPJ_G0015977	protein coding gene	Chr1:59931643-59949825 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015927	protein coding gene	Chr1:66234682-66255785 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016500	protein coding gene	Chr1:58499979-58520289 (-)
PWK/PhJ	MGP_PWKPhJ_G0015201	protein coding gene	Chr1:55760461-55780093 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014981	protein coding gene	Chr1:58027411-58045415 (-)
WSB/EiJ	MGP_WSBEiJ_G0015477	protein coding gene	Chr1:58204131-58223463 (-)

Human Ortholog

TMEM237, transmembrane protein 237

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM237, transmembrane protein 237
Synonyms

ALS2CR4, JBTS14
Links

HGNC:14432

NCBI Gene ID: 65062

neXtProt AC: NX_Q96Q45

UniProt: Q96Q45
Chr Location

chr2:201620184-201643570 (-) GRCh38

MGI Vertebrate Homology

Tmem237 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TMEM237
Gene Tree

Tmem237

Diseases

2 with human TMEM237 associations

				Human Disease	Mouse Models
				Joubert syndrome IDs Joubert syndrome DOID:0050777 ICD10CM:Q04.3 OMIM:PS213300 ORDO:475
				Joubert syndrome 14 IDs Joubert syndrome 14 DOID:0110983 OMIM:614424

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

22 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Gene trapped

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Tmem237
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

822
Tissues

62
cDNA Data

36
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem237

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All Sequences

57
RefSeq

10
UniProt

3
CCDS

CCDS14983.1, CCDS14984.1, CCDS87834.1

Ensembl

ENSMUSG00000038079 (Evidence)
NCBI Gene

381259

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038079	Ensembl Gene Model \| MGI Sequence Detail	19819	C57BL/6J	± kb
transcript	ENSMUST00000186794	Ensembl \| MGI Sequence Detail	1533	Not Applicable
polypeptide	ENSMUSP00000139823	Ensembl \| MGI Sequence Detail	427	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003976 transmembrane protein 237

(term hierarchy)
InterPro Domains

IPR029409 Transmembrane protein 237

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All nucleic 36

cDNA 36

Microarray probesets 3

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MGI:2685818

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 11
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmem237:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11816	Chr1:59159238-59159294 (-)	301 bp
Tssr11815	Chr1:59158907-59158954 (-)	636 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24