Gigyf2 MGI Mouse Gene Detail - MGI:2138584 - GRB10 interacting GYF protein 2

Symbol

Gigyf2
Name

GRB10 interacting GYF protein 2
Synonyms

2610016F01Rik, A830080H02Rik, mKIAA0642, Tnrc15

Feature Type

protein coding gene
IDs

MGI:2138584
NCBI Gene: 227331
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr1:87254720-87378518 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 44.23 cM
Mapping Data

3 experiments

SNPs within 2kb

1877 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2138584	protein coding gene	Chr1:87254653-87378532 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016263	protein coding gene	Chr1:88677319-88813018 (+)
A/J	MGP_AJ_G0016244	protein coding gene	Chr1:85361023-85488013 (+)
AKR/J	MGP_AKRJ_G0016205	protein coding gene	Chr1:87877627-88008199 (+)
BALB/cJ	MGP_BALBcJ_G0016201	protein coding gene	Chr1:85482051-85606949 (+)
C3H/HeJ	MGP_C3HHeJ_G0016029	protein coding gene	Chr1:88138706-88266383 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016657	protein coding gene	Chr1:92002000-92131124 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014379	protein coding gene	Chr1:79808586-79937740 (+)
CAST/EiJ	MGP_CASTEiJ_G0015614	protein coding gene	Chr1:87359744-87488269 (+)
CBA/J	MGP_CBAJ_G0016005	protein coding gene	Chr1:94903363-95050552 (+)
DBA/2J	MGP_DBA2J_G0016108	protein coding gene	Chr1:84664542-84789031 (+)
FVB/NJ	MGP_FVBNJ_G0016107	protein coding gene	Chr1:83723976-83849936 (+)
LP/J	MGP_LPJ_G0016179	protein coding gene	Chr1:89743489-89879554 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016133	protein coding gene	Chr1:98178560-98326590 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016700	protein coding gene	Chr1:87993940-88120651 (+)
PWK/PhJ	MGP_PWKPhJ_G0015401	protein coding gene	Chr1:83962341-84089088 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015181	protein coding gene	Chr1:86906362-87041224 (+)
WSB/EiJ	MGP_WSBEiJ_G0015678	protein coding gene	Chr1:87663583-87793389 (+)

Human Ortholog

GIGYF2, GRB10 interacting GYF protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GIGYF2, GRB10 interacting GYF protein 2
Synonyms

GYF2, PARK11, PERQ2, PERQ3, TNRC15
Links

HGNC:11960

NCBI Gene ID: 26058

neXtProt AC: NX_Q6Y7W6

UniProt: Q6Y7W6
Chr Location

2q37.1; chr2:232697299-232860605 (+) GRCh38

MGI Vertebrate Homology

Gigyf2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GIGYF2
Gene Tree

Gigyf2

Diseases

1 with human GIGYF2 associations

				Human Disease	Mouse Models
				Parkinson's disease IDs Parkinson's disease DOID:14330 ICD10CM:G20 ICD9CM:332 ICD9CM:332.0 KEGG:05012 MESH:D010300 NCI:C26845 OMIM:PS168600 ORDO:2828 UMLS_CUI:C0030567

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

25 phenotypes from 2 alleles in 2 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

105
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

95
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Gigyf2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

105 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit neonatal and postnatal lethality. Mice heterozygous for a knock-out allele exhibit impaired motor coordination with motor neuron degeneration.

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All GO Annotations

53
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

747
Tissues

24
cDNA Data

143
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gigyf2

ZFIN gigyf2

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All Sequences

121
RefSeq

26
UniProt

15
CCDS

CCDS15133.1, CCDS56636.1

Ensembl

ENSMUSG00000048000 (Evidence)
NCBI Gene

227331

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048000	Ensembl Gene Model \| MGI Sequence Detail	123799	C57BL/6J	± kb
transcript	ENSMUST00000174501	Ensembl \| MGI Sequence Detail	3876	Not Applicable
polypeptide	ENSMUSP00000133327	Ensembl \| MGI Sequence Detail	1291	Not Applicable

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UniProt

15 Sequences
Protein Ontology

PR:000007977 GRB10-interacting GYF protein 2

(term hierarchy)
InterPro Domains

IPR051640 GRB10-interacting GYF

IPR003169 GYF domain

IPR035445 GYF-like domain superfamily
GlyGen

Q6Y7W8 4 sites, 1 O-linked glycan (4 sites)

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All nucleic 146

cDNA 144

Primer pair 2

Microarray probesets 5

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MGI:1916462, MGI:2146509, MGI:3039589

Summaries

All 52

Developmental Gene Expression 5

Gene Ontology 7

Phenotypes 21
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:353281 Rybiczka-Tesulov M, et al., Circular RNAs regulate neuron size and migration of midbrain dopamine neurons during development. Nat Commun. 2024 Aug 8;15(1):6773

TSS for Gigyf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7838	Chr1:87254719-87254728 (+)	4 bp
Tssr7839	Chr1:87254730-87254764 (+)	27 bp
Tssr7840	Chr1:87254766-87254775 (+)	51 bp
Tssr7841	Chr1:87264330-87264335 (+)	9,613 bp
Tssr149	Chr1:87286097-87286101 (+)	31,379 bp
Tssr7842	Chr1:87287999-87288002 (+)	33,281 bp
Tssr7843	Chr1:87290385-87290387 (+)	35,666 bp
Tssr7844	Chr1:87331427-87331437 (+)	76,712 bp
Tssr7845	Chr1:87332669-87332682 (+)	77,956 bp
Tssr7846	Chr1:87332699-87332704 (+)	77,982 bp
Tssr7847	Chr1:87332709-87332720 (+)	77,995 bp
Tssr7848	Chr1:87368186-87368199 (+)	113,473 bp
Tssr7849	Chr1:87370735-87370737 (+)	116,016 bp
Tssr150	Chr1:87377005-87377008 (+)	122,287 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24