Ccnyl1 MGI Mouse Gene Detail - MGI:2138614

Symbol

Ccnyl1
Name

cyclin Y-like 1
Synonyms

9630037P07Rik

Feature Type

protein coding gene
IDs

MGI:2138614
NCBI Gene: 227210
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:64729963-64764805 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 32.74 cM
Mapping Data

2 experiments

SNPs within 2kb

737 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2138614	protein coding gene	Chr1:64729614-64764805 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016097	protein coding gene	Chr1:64868497-64903672 (+)
A/J	MGP_AJ_G0016080	protein coding gene	Chr1:62585271-62620445 (+)
AKR/J	MGP_AKRJ_G0016037	protein coding gene	Chr1:64341043-64378213 (+)
BALB/cJ	MGP_BALBcJ_G0016035	protein coding gene	Chr1:62681454-62716640 (+)
C3H/HeJ	MGP_C3HHeJ_G0015867	protein coding gene	Chr1:64612954-64650583 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016488	protein coding gene	Chr1:67377278-67416534 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014209	protein coding gene	Chr1:58644012-58681869 (+)
CAST/EiJ	MGP_CASTEiJ_G0015450	protein coding gene	Chr1:63875391-63914688 (+)
CBA/J	MGP_CBAJ_G0015839	protein coding gene	Chr1:69568374-69606898 (+)
DBA/2J	MGP_DBA2J_G0015940	protein coding gene	Chr1:61991644-62026854 (+)
FVB/NJ	MGP_FVBNJ_G0015943	protein coding gene	Chr1:61267778-61302942 (+)
LP/J	MGP_LPJ_G0016012	protein coding gene	Chr1:65773577-65808736 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015963	protein coding gene	Chr1:72432699-72470170 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016535	protein coding gene	Chr1:64323162-64358326 (+)
PWK/PhJ	MGP_PWKPhJ_G0015237	protein coding gene	Chr1:61375357-61418354 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015016	protein coding gene	Chr1:63809488-63846088 (+)
WSB/EiJ	MGP_WSBEiJ_G0015512	protein coding gene	Chr1:64027549-64065251 (+)

Human Ortholog

CCNYL1, cyclin Y like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCNYL1, cyclin Y like 1
Links

HGNC:26868

NCBI Gene ID: 151195

neXtProt AC: NX_Q8N7R7

UniProt: Q8N7R7
Chr Location

2q33.3; chr2:207711540-207761839 (+) GRCh38

MGI Vertebrate Homology

Ccnyl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CCNYL1
Protein SuperFamily

Cyclin_CG14939
Gene Tree

Ccnyl1

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Ccnyl1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit male infertility associated with asthenozoospermia and teratozoospermia.

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

750
Tissues

16
cDNA Data

42
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CCNYL1

Xenbase ccnyl1

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All Sequences

46
RefSeq

6
UniProt

2
CCDS

CCDS48281.1

Ensembl

ENSMUSG00000070871 (Evidence)
NCBI Gene

227210

			Length	Strain/Species	Flank
genomic	227210	NCBI Gene Model \| MGI Sequence Detail	34843	C57BL/6J	± kb
transcript	NM_001097644	RefSeq \| MGI Sequence Detail	2940	C57BL/6
polypeptide	D3YUJ3	UniProt \| EBI \| MGI Sequence Detail	367	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR013763 Cyclin-like domain

IPR036915 Cyclin-like superfamily

IPR006671 Cyclin, N-terminal

IPR012399 Cyclin Y

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All nucleic 44

cDNA 42

Primer pair 1

Other 1

Microarray probesets 4

Summaries

All 35

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ccnyl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7096	Chr1:64729525-64729530 (+)	-435 bp
Tssr7097	Chr1:64729602-64729626 (+)	-349 bp
Tssr7098	Chr1:64729950-64729962 (+)	-7 bp
Tssr7099	Chr1:64730026-64730031 (+)	66 bp
Tssr7100	Chr1:64730072-64730092 (+)	119 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24