Cdc123 MGI Mouse Gene Detail - MGI:2138811

Symbol

Cdc123
Name

cell division cycle 123
Synonyms

G431001I09Rik

Feature Type

protein coding gene
IDs

MGI:2138811
NCBI Gene: 98828
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr2:5799105-5849975 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 3.62 cM
Mapping Data

2 experiments

SNPs within 2kb

1408 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2138811	protein coding gene	Chr2:5799105-5849988 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025323	protein coding gene	Chr2:2923317-2977460 (-)
A/J	MGP_AJ_G0025300	protein coding gene	Chr2:2785842-2837820 (-)
AKR/J	MGP_AKRJ_G0025268	protein coding gene	Chr2:2868010-2920798 (-)
BALB/cJ	MGP_BALBcJ_G0025296	protein coding gene	Chr2:2765551-2816597 (-)
C3H/HeJ	MGP_C3HHeJ_G0025056	protein coding gene	Chr2:2831484-2881106 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025738	protein coding gene	Chr2:2998534-3053615 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023152	protein coding gene	Chr2:2596192-2647528 (-)
CAST/EiJ	MGP_CASTEiJ_G0024519	protein coding gene	Chr2:2870420-2923640 (-)
CBA/J	MGP_CBAJ_G0025035	protein coding gene	Chr2:3122138-3189196 (-)
DBA/2J	MGP_DBA2J_G0025167	protein coding gene	Chr2:2730269-2781269 (-)
FVB/NJ	MGP_FVBNJ_G0025129	protein coding gene	Chr2:2722941-2776110 (-)
LP/J	MGP_LPJ_G0025253	protein coding gene	Chr2:2873313-2924611 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025161	protein coding gene	Chr2:2980617-3036309 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025796	protein coding gene	Chr2:2855040-2912369 (-)
PWK/PhJ	MGP_PWKPhJ_G0024270	protein coding gene	Chr2:2725830-2775900 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024070	protein coding gene	Chr2:2842018-2897416 (-)
WSB/EiJ	MGP_WSBEiJ_G0024589	protein coding gene	Chr2:2888159-2946680 (-)

Human Ortholog

CDC123, cell division cycle 123

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDC123, cell division cycle 123
Synonyms

C10orf7, D123
Links

HGNC:16827

NCBI Gene ID: 8872

neXtProt AC: NX_O75794

UniProt: O75794
Chr Location

10p14-p13; chr10:12195965-12250589 (+) GRCh38

MGI Vertebrate Homology

Cdc123 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDC123
Protein SuperFamily

Cdc123
Gene Tree

Cdc123

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Gene trapped

19
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

11
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

140

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cdc123

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All Sequences

57
RefSeq

12
UniProt

2
CCDS

CCDS15666.1

Ensembl

ENSMUSG00000039128 (Evidence)
NCBI Gene

98828

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039128	Ensembl Gene Model \| MGI Sequence Detail	50871	C57BL/6J	± kb
transcript	ENSMUST00000043864	Ensembl \| MGI Sequence Detail	1827	Not Applicable
polypeptide	ENSMUSP00000043033	Ensembl \| MGI Sequence Detail	336	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005183 cell division cycle protein 123

(term hierarchy)
InterPro Domains

IPR009772 Cell division cycle protein 123

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All nucleic 140

cDNA 140

Microarray probesets 4

Summaries

All 36

Gene Ontology 4

Phenotypes 12
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cdc123:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr22429	Chr2:5849728-5849796 (-)	213 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24