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Dlgap4 Gene Detail
Summary
  • Symbol
    Dlgap4
  • Name
    DLG associated protein 4
  • Synonyms
    DAP4, MGC:37636, mKIAA0964, PSD-95/SAP90 binding protein 4, SAP90/PSD-95-associated protein 4, Sapap4, WBP16
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138865
    NCBI Gene: 228836
  • Alliance
    gene page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:156455625-156606283 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 77.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3986 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138865
 protein coding gene Chr2:156455431-156606283 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026766
 protein coding gene Chr2:161522348-161683963 (+)
A/J MGP_AJ_G0026732
 protein coding gene Chr2:155094627-155249477 (+)
AKR/J MGP_AKRJ_G0026703
 protein coding gene Chr2:159600276-159760905 (+)
BALB/cJ MGP_BALBcJ_G0026741
 protein coding gene Chr2:155386597-155536938 (+)
C3H/HeJ MGP_C3HHeJ_G0026484
 protein coding gene Chr2:159939653-160098309 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027190
 protein coding gene Chr2:166236332-166403597 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024560
 protein coding gene Chr2:148558430-148708669 (+)
CAST/EiJ MGP_CASTEiJ_G0025945
 protein coding gene Chr2:160283500-160445505 (+)
CBA/J MGP_CBAJ_G0026461
 protein coding gene Chr2:172299240-172474922 (+)
DBA/2J MGP_DBA2J_G0026598
 protein coding gene Chr2:154265102-154418618 (+)
FVB/NJ MGP_FVBNJ_G0026565
 protein coding gene Chr2:152633911-152788195 (+)
LP/J MGP_LPJ_G0026703
 protein coding gene Chr2:161642172-161805619 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026586
 protein coding gene Chr2:176201939-176364644 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027246
 protein coding gene Chr2:159464988-159622218 (+)
PWK/PhJ MGP_PWKPhJ_G0025679
 protein coding gene Chr2:153765443-153924957 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025482
 protein coding gene Chr2:158505070-158567914 (+)
WSB/EiJ MGP_WSBEiJ_G0026015
 protein coding gene Chr2:160352701-160516261 (+)



Homology
more
  • Human Ortholog
    DLGAP4, DLG associated protein 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLGAP4, DLG associated protein 4
  • Synonyms
    DAP-4, DAP4, DLP4, SAPAP-4, SAPAP4
  • Links
    NCBI Gene ID: 22839
    neXtProt AC: NX_Q9Y2H0
    UniProt: Q9Y2H0

  • Chr Location
    20q11.23; chr20:36306336-36528637 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dlgap4 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display impaired dendrite morphology, increased mean postsynaptic density area, and impaired vocal communication and social interaction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    908
  • Tissues
    45
  • cDNA Data
    12
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061689 Ensembl Gene Model | MGI Sequence Detail 150659 C57BL/6J ±  kb
    transcript ENSMUST00000169464 Ensembl | MGI Sequence Detail 4851 Not Applicable  
    polypeptide ENSMUSP00000126980 Ensembl | MGI Sequence Detail 992 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 12
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2385162
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:71028 Bedford MT, et al., A novel pro-Arg motif recognized by WW domains. J Biol Chem. 2000 Apr 7;275(14):10359-69
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory