Stard7 MGI Mouse Gene Detail - MGI:2139090 - StAR related lipid transfer domain containing 7

Symbol

Stard7
Name

StAR related lipid transfer domain containing 7

Feature Type

protein coding gene
IDs

MGI:2139090
NCBI Gene: 99138
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:127112138-127140852 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 61.88 cM
Mapping Data

3 experiments

SNPs within 2kb

559 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2139090	protein coding gene	Chr2:127112123-127140855 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026455	protein coding gene	Chr2:130547867-130582333 (+)
A/J	MGP_AJ_G0026419	protein coding gene	Chr2:125254188-125283060 (+)
AKR/J	MGP_AKRJ_G0026394	protein coding gene	Chr2:128829017-128863159 (+)
BALB/cJ	MGP_BALBcJ_G0026431	protein coding gene	Chr2:125524015-125553521 (+)
C3H/HeJ	MGP_C3HHeJ_G0026174	protein coding gene	Chr2:129349812-129378768 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026876	protein coding gene	Chr2:134643728-134677758 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024253	protein coding gene	Chr2:120098142-120126836 (+)
CAST/EiJ	MGP_CASTEiJ_G0025635	protein coding gene	Chr2:129557281-129585696 (+)
CBA/J	MGP_CBAJ_G0026154	protein coding gene	Chr2:139632244-139663056 (+)
DBA/2J	MGP_DBA2J_G0026288	protein coding gene	Chr2:124665067-124694277 (+)
FVB/NJ	MGP_FVBNJ_G0026252	protein coding gene	Chr2:123310814-123339414 (+)
LP/J	MGP_LPJ_G0026393	protein coding gene	Chr2:130784118-130816212 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026272	protein coding gene	Chr2:143666354-143696183 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026931	protein coding gene	Chr2:128861532-128891102 (+)
PWK/PhJ	MGP_PWKPhJ_G0025371	protein coding gene	Chr2:124209910-124238937 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025173	protein coding gene	Chr2:127935508-127969316 (+)
WSB/EiJ	MGP_WSBEiJ_G0025709	protein coding gene	Chr2:129753432-129784203 (+)

Human Ortholog

STARD7, StAR related lipid transfer domain containing 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STARD7, StAR related lipid transfer domain containing 7
Synonyms

ADCME, BAFME2, FAME, FAME2, FCMTE2, GTT1
Links

HGNC:18063

NCBI Gene ID: 56910

neXtProt AC: NX_Q9NQZ5

UniProt: Q9NQZ5
Chr Location

2q11.2; chr2:96184859-96208827 (-) GRCh38

MGI Vertebrate Homology

Stard7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: STARD7
Gene Tree

Stard7

Diseases

1 with human STARD7 associations

				Human Disease	Mouse Models
				familial adult myoclonic epilepsy 2 IDs familial adult myoclonic epilepsy 2 DOID:0111692 OMIM:607876

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Gene trapped

2
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Stard7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Heterozygous KO results in exaggerated allergic response (lung inflammation, increased epithelial barrier permeability and airway responsiveness) and atopic dermatitis.

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

21
cDNA Data

175
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase stard7

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All Sequences

69
RefSeq

7
UniProt

6
CCDS

CCDS16698.2

Ensembl

ENSMUSG00000027367 (Evidence)
NCBI Gene

99138

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027367	Ensembl Gene Model \| MGI Sequence Detail	28715	C57BL/6J	± kb
transcript	ENSMUST00000125049	Ensembl \| MGI Sequence Detail	2869	Not Applicable
polypeptide	ENSMUSP00000116374	Ensembl \| MGI Sequence Detail	409	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000015722 StAR-related lipid transfer protein 7, mitochondrial

(term hierarchy)
InterPro Domains

IPR041949 STARD7, START domain

IPR002913 START domain

IPR051213 START domain-containing lipid transfer

IPR023393 START-like domain superfamily

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All nucleic 177

cDNA 176

Primer pair 1

Microarray probesets 5

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MGI:2139121, MGI:2139373

Summaries

All 41

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 13
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Stard7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20003	Chr2:127112128-127112191 (+)	22 bp
Tssr20004	Chr2:127112614-127112667 (+)	503 bp
Tssr20005	Chr2:127112677-127112694 (+)	548 bp
Tssr20006	Chr2:127119603-127119607 (+)	7,467 bp
Tssr636	Chr2:127119852-127119861 (+)	7,719 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24