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Tm9sf4 Gene Detail
Summary
  • Symbol
    Tm9sf4
  • Name
    transmembrane 9 superfamily member 4
  • Synonyms
    mKIAA0255
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139220
    NCBI Gene: 99237
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:153003223-153052386 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 75.41 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1023 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139220
 protein coding gene Chr2:152999279-153052386 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026688
 protein coding gene Chr2:157774126-157825801 (+)
A/J MGP_AJ_G0026654
 protein coding gene Chr2:151463228-151513732 (+)
AKR/J MGP_AKRJ_G0026624
 protein coding gene Chr2:155889293-155940606 (+)
BALB/cJ MGP_BALBcJ_G0026663
 protein coding gene Chr2:151773108-151824131 (+)
C3H/HeJ MGP_C3HHeJ_G0026406
 protein coding gene Chr2:156260962-156318344 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027112
 protein coding gene Chr2:162346575-162414604 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024483
 protein coding gene Chr2:145046475-145092828 (+)
CAST/EiJ MGP_CASTEiJ_G0025867
 protein coding gene Chr2:156516547-156571337 (+)
CBA/J MGP_CBAJ_G0026384
 protein coding gene Chr2:168329165-168382695 (+)
DBA/2J MGP_DBA2J_G0026520
 protein coding gene Chr2:150672539-150721565 (+)
FVB/NJ MGP_FVBNJ_G0026486
 protein coding gene Chr2:149134908-149190460 (+)
LP/J MGP_LPJ_G0026624
 protein coding gene Chr2:157918597-157974403 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026507
 protein coding gene Chr2:172373831-172428183 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027168
 protein coding gene Chr2:155788446-155843577 (+)
PWK/PhJ MGP_PWKPhJ_G0025601
 protein coding gene Chr2:150204890-150256063 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025404
 protein coding gene Chr2:154622911-154672284 (+)
WSB/EiJ MGP_WSBEiJ_G0025937
 protein coding gene Chr2:156685785-156738137 (+)



Homology
more
  • Human Ortholog
    TM9SF4, transmembrane 9 superfamily member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TM9SF4, transmembrane 9 superfamily member 4
  • Synonyms
    dJ836N17.2
  • Links
    NCBI Gene ID: 9777
    neXtProt AC: NX_Q92544
    UniProt: Q92544

  • Chr Location
    20q11.21; chr20:32109714-32167258 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit abnormal hair follicles and sebaceous glands, vertebrae and rib abnormalities, and increased circulating cholesterol, calcium, albumin, and total protein levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    42
  • cDNA Data
    139
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000068040 Ensembl Gene Model | MGI Sequence Detail 49164 C57BL/6J ±  kb
    transcript ENSMUST00000089027 Ensembl | MGI Sequence Detail 3896 Not Applicable  
    polypeptide ENSMUSP00000086422 Ensembl | MGI Sequence Detail 643 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 139
      cDNA 139

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2138821
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:348683 Zhao R, et al., Comparative analysis of the expression patterns of TM9SF family members in mice. Gene Expr Patterns. 2024 May 6;52:119366
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory