About   Help   FAQ
Hrh3 Gene Detail
Summary
  • Symbol
    Hrh3
  • Name
    histamine receptor H3
  • Synonyms
    Eae8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139279
    NCBI Gene: 99296
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:179741258-179746264 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 102.62 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    136 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139279
 protein coding gene Chr2:179741258-179746281 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026986
 protein coding gene Chr2:186599978-186605001 (-)
A/J MGP_AJ_G0026952
 protein coding gene Chr2:178932976-178937999 (-)
AKR/J MGP_AKRJ_G0026922
 protein coding gene Chr2:184287442-184292465 (-)
BALB/cJ MGP_BALBcJ_G0026961
 protein coding gene Chr2:179397117-179402140 (-)
C3H/HeJ MGP_C3HHeJ_G0026702
 protein coding gene Chr2:184642040-184647063 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027407
 protein coding gene Chr2:191992291-191997314 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024774
 protein coding gene Chr2:169624599-169629638 (-)
CAST/EiJ MGP_CASTEiJ_G0026161
 protein coding gene Chr2:182886811-182891839 (-)
CBA/J MGP_CBAJ_G0026679
 protein coding gene Chr2:198973188-198978211 (-)
DBA/2J MGP_DBA2J_G0026817
 protein coding gene Chr2:178028395-178033418 (-)
FVB/NJ MGP_FVBNJ_G0026783
 protein coding gene Chr2:176631137-176636925 (-)
LP/J MGP_LPJ_G0026918
 protein coding gene Chr2:186591671-186596694 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026802
 protein coding gene Chr2:201601220-201606243 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027466
 protein coding gene Chr2:184253655-184258678 (-)
PWK/PhJ MGP_PWKPhJ_G0025897
 protein coding gene Chr2:175538960-175543988 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025697
 protein coding gene Chr2:180742956-180747983 (-)
WSB/EiJ MGP_WSBEiJ_G0026233
 protein coding gene Chr2:185219016-185225358 (-)



Homology
more
  • Human Ortholog
    HRH3, histamine receptor H3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HRH3, histamine receptor H3
  • Synonyms
    GPCR97, HH3R
  • Links
    NCBI Gene ID: 11255
    neXtProt AC: NX_Q9Y5N1
    UniProt: Q9Y5N1

  • Chr Location
    20q13.33; chr20:62214960-62220278 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 5 alleles in 8 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced locomotor activity and body temperature, and attenuated behavioral responses to the drugs thioperamide, methamphetamine, and scopolamine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    13
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 99296 NCBI Gene Model | MGI Sequence Detail 5007 C57BL/6J ±  kb
    transcript NM_001409455 RefSeq | MGI Sequence Detail 3863 ZRU/MplStud  
    polypeptide P58406 UniProt | EBI | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 2
      cDNA 9
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1309474
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 29
    • Earliest
      J:29171 Baker D, et al., Genetic analysis of experimental allergic encephalomyelitis in mice. J Immunol. 1995 Oct 15;155(8):4046-51
    • Latest
      J:337893 Davies S, et al., Effect of moderate prenatal ethanol exposure on the differential expression of two histamine H3 receptor isoforms in different brain regions of adult rat offspring. Front Neurosci. 2023;17:1192096
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory