Ppm1l MGI Mouse Gene Detail - MGI:2139740 - protein phosphatase 1 (formerly 2C)-like

Symbol

Ppm1l
Name

protein phosphatase 1 (formerly 2C)-like
Synonyms

5930404J21Rik, Pp2ce, PP2C-epsilon

Feature Type

protein coding gene
IDs

MGI:2139740
NCBI Gene: 242083
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr3:69224251-69468131 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 32.21 cM
Mapping Data

2 experiments

SNPs within 2kb

7645 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2139740	protein coding gene	Chr3:69224194-69468135 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027295	protein coding gene	Chr3:68567611-68824291 (+)
A/J	MGP_AJ_G0027257	protein coding gene	Chr3:66508942-66754788 (+)
AKR/J	MGP_AKRJ_G0027225	protein coding gene	Chr3:67952153-68209355 (+)
BALB/cJ	MGP_BALBcJ_G0027268	protein coding gene	Chr3:66390489-66645678 (+)
C3H/HeJ	MGP_C3HHeJ_G0027012	protein coding gene	Chr3:68169166-68431301 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027714	protein coding gene	Chr3:71138602-71397173 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025067	protein coding gene	Chr3:62771886-63033140 (+)
CAST/EiJ	MGP_CASTEiJ_G0026459	protein coding gene	Chr3:68131728-68399071 (+)
CBA/J	MGP_CBAJ_G0026987	protein coding gene	Chr3:73322130-73593345 (+)
DBA/2J	MGP_DBA2J_G0027123	protein coding gene	Chr3:66014044-66257367 (+)
FVB/NJ	MGP_FVBNJ_G0027091	protein coding gene	Chr3:64638452-64883448 (+)
LP/J	MGP_LPJ_G0027231	protein coding gene	Chr3:69495645-69762045 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027110	protein coding gene	Chr3:77922267-78185993 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027772	protein coding gene	Chr3:67833846-68089447 (+)
PWK/PhJ	MGP_PWKPhJ_G0026193	protein coding gene	Chr3:65748563-66012388 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026009	protein coding gene	Chr3:66924030-67176297 (+)
WSB/EiJ	MGP_WSBEiJ_G0026537	protein coding gene	Chr3:67976420-68234326 (+)

Human Ortholog

PPM1L, protein phosphatase, Mg2+/Mn2+ dependent 1L

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPM1L, protein phosphatase, Mg2+/Mn2+ dependent 1L
Synonyms

PP2CE, PP2C-epsilon, PPM1-LIKE
Links

HGNC:16381

NCBI Gene ID: 151742

neXtProt AC: NX_Q5SGD2

UniProt: Q5SGD2
Chr Location

3q25.33-q26.1; chr3:160755602-161078902 (+) GRCh38

MGI Vertebrate Homology

Ppm1l stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PPM1L
Gene Tree

Ppm1l

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References

1 with disease annotations

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Phenotype Summary

21 phenotypes from 2 alleles in 3 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Ppm1l
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null allele show increased body weight and total fat mass, higher blood pressure and plasma glucose levels, lower free fatty acid levels and improved glucose tolerance. Homozygotes for another null allele show postnatal lethality, motor deficits and altered forebrain morphology.

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All GO Annotations

20
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1031
Tissues

63
cDNA Data

71
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppm1l

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All Sequences

65
RefSeq

4
UniProt

1
CCDS

CCDS17405.1

Ensembl

ENSMUSG00000027784 (Evidence)
NCBI Gene

242083

			Length	Strain/Species	Flank
genomic	242083	NCBI Gene Model \| MGI Sequence Detail	243881	C57BL/6J	± kb
transcript	NM_178726	RefSeq \| MGI Sequence Detail	3962	C57BL/6
polypeptide	Q8BHN0	UniProt \| EBI \| MGI Sequence Detail	360	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013099 protein phosphatase 1L

(term hierarchy)
EC

3.1.3.16
InterPro Domains

IPR000222 PPM-type phosphatase, divalent cation binding

IPR001932 PPM-type phosphatase-like domain

IPR036457 PPM-type phosphatase-like domain superfamily

IPR015655 Protein phosphatase 2C
GlyGen

Q8BHN0 3 sites, 3 N-linked glycans (3 sites)

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All nucleic 72

cDNA 71

Primer pair 1

Microarray probesets 8

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MGI:2139948

Summaries

All 45

Developmental Gene Expression 4

Diseases 1

Gene Ontology 8

Phenotypes 10
Earliest

J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
Latest

J:306226 Firulli BA, et al., HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure. Cardiovasc Res. 2020 Mar 1;116(3):605-618

TSS for Ppm1l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29535	Chr3:69224190-69224202 (+)	-55 bp
Tssr29536	Chr3:69224206-69224270 (+)	-13 bp
Tssr29537	Chr3:69247822-69247826 (+)	23,573 bp
Tssr29538	Chr3:69251211-69251222 (+)	26,966 bp
Tssr29539	Chr3:69251332-69251349 (+)	27,090 bp
Tssr29540	Chr3:69251490-69251505 (+)	27,247 bp
Tssr29541	Chr3:69281062-69281107 (+)	56,834 bp
Tssr29542	Chr3:69293729-69293735 (+)	69,481 bp
Tssr29543	Chr3:69304642-69304645 (+)	80,393 bp
Tssr29544	Chr3:69456283-69456309 (+)	232,045 bp
Tssr29545	Chr3:69460687-69460705 (+)	236,445 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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