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Clca2 Gene Detail
Summary
  • Symbol
    Clca2
  • Name
    chloride channel accessory 2
  • Synonyms
    Clca5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139758
    NCBI Gene: 229933
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:144776024-144805204 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 69.31 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1077 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139758
 protein coding gene Chr3:144776021-144805204 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027957
 protein coding gene Chr3:148460929-148489993 (-)
A/J MGP_AJ_G0027916
 protein coding gene Chr3:143181180-143210421 (-)
AKR/J MGP_AKRJ_G0027882
 protein coding gene Chr3:146971238-147000397 (-)
BALB/cJ MGP_BALBcJ_G0027928
 protein coding gene Chr3:142989710-143018851 (-)
C3H/HeJ MGP_C3HHeJ_G0027658
 protein coding gene Chr3:147341766-147370937 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028371
 protein coding gene Chr3:153571503-153600673 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025710
 protein coding gene Chr3:138276033-138305800 (-)
CAST/EiJ MGP_CASTEiJ_G0027111
 protein coding gene Chr3:147297960-147327343 (-)
CBA/J MGP_CBAJ_G0027633
 protein coding gene Chr3:158890608-158919954 (-)
DBA/2J MGP_DBA2J_G0027773
 protein coding gene Chr3:142335686-142364798 (-)
FVB/NJ MGP_FVBNJ_G0027740
 protein coding gene Chr3:139743526-139772685 (-)
LP/J MGP_LPJ_G0027884
 protein coding gene Chr3:149855471-149888835 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027773
 protein coding gene Chr3:167226657-167258130 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028430
 protein coding gene Chr3:146572972-146602132 (-)
PWK/PhJ MGP_PWKPhJ_G0026834
 protein coding gene Chr3:142179045-142208444 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026662
 protein coding gene Chr3:144743976-144774235 (-)
WSB/EiJ MGP_WSBEiJ_G0027191
 protein coding gene Chr3:147526589-147557010 (-)



Homology
more
  • Human Ortholog
    CLCA2, chloride channel accessory 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLCA2, chloride channel accessory 2
  • Synonyms
    CACC, CaCC-3, CACC3, CLCRG2
  • Links
    NCBI Gene ID: 9635
    neXtProt AC: NX_Q9UQC9
    UniProt: Q9UQC9

  • Chr Location
    1p22.3; chr1:86424171-86456553 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation exhibit increases in liver weight to body weight ratio and hepatocyte hypertrophy; one incidence of multifocal hepatic necrosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    851
  • Tissues
    61
  • cDNA Data
    16
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036960 Ensembl Gene Model | MGI Sequence Detail 29181 C57BL/6J ±  kb
    transcript ENSMUST00000040465 Ensembl | MGI Sequence Detail 3986 Not Applicable  
    polypeptide ENSMUSP00000036029 Ensembl | MGI Sequence Detail 942 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000005524 calcium-activated chloride channel regulator 2
      (term hierarchy)
    • EC
      3.4.-.-
    • InterPro Domains
      IPR013642 Calcium-activated chloride channel, N-terminal
      IPR004727 Calcium-activated chloride channel protein, chordata
      IPR051266 Calcium-activated chloride channel regulator
      IPR036465 von Willebrand factor A-like domain superfamily
      IPR002035 von Willebrand factor, type A
    • GlyGen
      Q8BG22 10 sites
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 16
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory