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Slc9b2 Gene Detail
Summary
  • Symbol
    Slc9b2
  • Name
    solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
  • Synonyms
    C80638, NHA2, nha-oc, NHE10, Nhedc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140077
    NCBI Gene: 97086
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:135013083-135048606 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 62.55 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1506 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140077
 protein coding gene Chr3:135013083-135051148 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027904
 protein coding gene Chr3:138179734-138218657 (+)
A/J MGP_AJ_G0027862
 protein coding gene Chr3:133330068-133367913 (+)
AKR/J MGP_AKRJ_G0027827
 protein coding gene Chr3:136862459-136901628 (+)
BALB/cJ MGP_BALBcJ_G0027875
 protein coding gene Chr3:133186594-133224652 (+)
C3H/HeJ MGP_C3HHeJ_G0027604
 protein coding gene Chr3:137200137-137238474 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028318
 protein coding gene Chr3:143018872-143057977 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025656
 protein coding gene Chr3:128573360-128608535 (+)
CAST/EiJ MGP_CASTEiJ_G0027060
 protein coding gene Chr3:136931362-136971442 (+)
CBA/J MGP_CBAJ_G0027580
 protein coding gene Chr3:147859105-147896621 (+)
DBA/2J MGP_DBA2J_G0027720
 protein coding gene Chr3:132495578-132532780 (+)
FVB/NJ MGP_FVBNJ_G0027687
 protein coding gene Chr3:129986270-130023736 (+)
LP/J MGP_LPJ_G0027830
 protein coding gene Chr3:139619930-139658603 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027718
 protein coding gene Chr3:155979337-156017401 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028376
 protein coding gene Chr3:136402078-136439981 (+)
PWK/PhJ MGP_PWKPhJ_G0026784
 protein coding gene Chr3:132208308-132246182 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026610
 protein coding gene Chr3:134476782-134517298 (+)
WSB/EiJ MGP_WSBEiJ_G0027139
 protein coding gene Chr3:137187945-137226762 (+)



Homology
more
  • Human Ortholog
    SLC9B2, solute carrier family 9 member B2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC9B2, solute carrier family 9 member B2
  • Synonyms
    NHA2, NHE10, NHEDC2
  • Links
    NCBI Gene ID: 133308
    neXtProt AC: NX_Q86UD5
    UniProt: Q86UD5

  • Chr Location
    4q24; chr4:103018029-103085829 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 4 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele are viable and overtly normal, with no detectable abnormalities in osteoclast differentiation and function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    777
  • Tissues
    15
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 97086 NCBI Gene Model | MGI Sequence Detail 35524 C57BL/6J ±  kb
    transcript NM_178877 RefSeq | MGI Sequence Detail 2028 C57BL/6  
    polypeptide Q5BKR2 UniProt | EBI | MGI Sequence Detail 547 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 13
      Phenotypes 21
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory