Tdrd7 MGI Mouse Gene Detail - MGI:2140279 - tudor domain containing 7

Symbol

Tdrd7
Name

tudor domain containing 7
Synonyms

5730495N10Rik

Feature Type

protein coding gene
IDs

MGI:2140279
NCBI Gene: 100121
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr4:45965334-46034761 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 24.48 cM
Mapping Data

2 experiments

SNPs within 2kb

1637 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2140279	protein coding gene	Chr4:45965334-46034766 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028250	protein coding gene	Chr4:44235790-44308259 (+)
A/J	MGP_AJ_G0028209	protein coding gene	Chr4:42639431-42707952 (+)
AKR/J	MGP_AKRJ_G0028159	protein coding gene	Chr4:43661107-43737865 (+)
BALB/cJ	MGP_BALBcJ_G0028229	protein coding gene	Chr4:42722821-42803020 (+)
C3H/HeJ	MGP_C3HHeJ_G0027950	protein coding gene	Chr4:44272504-44344665 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028670	protein coding gene	Chr4:45875400-45952304 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025979	protein coding gene	Chr4:40029779-40097782 (+)
CAST/EiJ	MGP_CASTEiJ_G0027389	protein coding gene	Chr4:43825471-43898019 (+)
CBA/J	MGP_CBAJ_G0027916	protein coding gene	Chr4:47323895-47401421 (+)
DBA/2J	MGP_DBA2J_G0028066	protein coding gene	Chr4:42532098-42602023 (+)
FVB/NJ	MGP_FVBNJ_G0028033	protein coding gene	Chr4:41772736-41843277 (+)
LP/J	MGP_LPJ_G0028165	protein coding gene	Chr4:44288366-44363919 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028057	protein coding gene	Chr4:50437418-50516863 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028705	protein coding gene	Chr4:43883884-43957048 (+)
PWK/PhJ	MGP_PWKPhJ_G0027114	protein coding gene	Chr4:42619685-42690080 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026942	protein coding gene	Chr4:43380382-43449959 (+)
WSB/EiJ	MGP_WSBEiJ_G0027467	protein coding gene	Chr4:43783780-43858022 (+)

Human Ortholog

TDRD7, tudor domain containing 7

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TDRD7, tudor domain containing 7
Synonyms

CATC4, PCTAIRE2BP, TRAP
Links

HGNC:30831

NCBI Gene ID: 23424

neXtProt AC: NX_Q8NHU6

UniProt: Q8NHU6
Chr Location

9q22.33; chr9:97412096-97496125 (+) GRCh38

MGI Vertebrate Homology

Tdrd7 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TDRD7
Gene Tree

Tdrd7

Diseases

1 with human TDRD7 associations

				Human Disease	Mouse Models
				cataract 36 IDs cataract 36 DOID:0110247 OMIM:613887

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

15 phenotypes from 2 alleles in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
6 images
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (ENU)

1
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene causes arrest of spermatogenesis, male sterility, glaucoma, and cataracts. Aging mice homozygous for an ENU-induced (null) allele show additional ocular phenotypes including an enlarged anterior chamber, lens extrusion, a flat iris, uveitis, and optic neuropathy.

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All GO Annotations

26
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

754
Tissues

34
cDNA Data

88
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tdrd7

ZFIN tdrd7a

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All Sequences

68
RefSeq

16
UniProt

4
CCDS

CCDS18142.1, CCDS71381.1

Ensembl

ENSMUSG00000035517 (Evidence)
NCBI Gene

100121

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035517	Ensembl Gene Model \| MGI Sequence Detail	69428	C57BL/6J	± kb
transcript	ENSMUST00000107777	Ensembl \| MGI Sequence Detail	3655	Not Applicable
polypeptide	ENSMUSP00000103406	Ensembl \| MGI Sequence Detail	1119	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000029784 tudor domain-containing protein 7

(term hierarchy)
PDB

2LH9, 2LY1, 2LY2
InterPro Domains

IPR041966 LOTUS-like domain

IPR025605 OST-HTH/LOTUS domain

IPR035437 SNase-like, OB-fold superfamily

IPR047448 TDRD7, second Tudor domain

IPR037978 TDRD7, third LOTUS domain

IPR047449 TDRD7, third Tudor domain

IPR002999 Tudor domain

IPR050621 Tudor domain-containing

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All nucleic 90

cDNA 88

Primer pair 1

Other 1

Microarray probesets 2

Summaries

All 37

Developmental Gene Expression 9

Gene Ontology 6

Phenotypes 9
Earliest

J:68708 Hrabe de Angelis MH, et al., Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet. 2000 Aug;25(4):444-7
Latest

J:308692 Anand D, et al., Genome-Wide Analysis of Differentially Expressed miRNAs and Their Associated Regulatory Networks in Lenses Deficient for the Congenital Cataract-Linked Tudor Domain Containing Protein TDRD7. Front Cell Dev Biol. 2021;9:615761

TSS for Tdrd7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37084	Chr4:45965327-45965342 (+)	1 bp
Tssr1164	Chr4:45972144-45972174 (+)	6,825 bp
Tssr37085	Chr4:45972235-45972245 (+)	6,906 bp
Tssr37086	Chr4:45972288-45972325 (+)	6,973 bp
Tssr37087	Chr4:45972337-45972365 (+)	7,017 bp
Tssr37088	Chr4:45972375-45972386 (+)	7,047 bp
Tssr37089	Chr4:45972394-45972405 (+)	7,066 bp
Tssr37090	Chr4:45972673-45972697 (+)	7,351 bp
Tssr37091	Chr4:45972766-45972787 (+)	7,443 bp
Tssr37092	Chr4:45972792-45972810 (+)	7,467 bp
Tssr37093	Chr4:45998955-45998966 (+)	33,627 bp
Tssr37094	Chr4:45998989-45998998 (+)	33,660 bp
Tssr37095	Chr4:46000448-46000474 (+)	35,127 bp
Tssr37096	Chr4:46031378-46031381 (+)	66,046 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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