Pafah2 MGI Mouse Gene Detail - MGI:2140321 - platelet-activating factor acetylhydrolase 2

Symbol

Pafah2
Name

platelet-activating factor acetylhydrolase 2
Synonyms

2310074E22Rik

Feature Type

protein coding gene
IDs

MGI:2140321
NCBI Gene: 100163
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr4:134123631-134154723 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 66.68 cM
Mapping Data

3 experiments

SNPs within 2kb

989 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2140321	protein coding gene	Chr4:134123631-134154724 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028926	protein coding gene	Chr4:136752050-136782909 (+)
A/J	MGP_AJ_G0028885	protein coding gene	Chr4:130993479-131024213 (+)
AKR/J	MGP_AKRJ_G0028837	protein coding gene	Chr4:134751589-134782080 (+)
BALB/cJ	MGP_BALBcJ_G0028909	protein coding gene	Chr4:131634666-131666268 (+)
C3H/HeJ	MGP_C3HHeJ_G0028623	protein coding gene	Chr4:134988682-135019753 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029350	protein coding gene	Chr4:141683272-141717550 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026621	protein coding gene	Chr4:124052492-124083731 (+)
CAST/EiJ	MGP_CASTEiJ_G0028055	protein coding gene	Chr4:133114542-133147877 (+)
CBA/J	MGP_CBAJ_G0028588	protein coding gene	Chr4:145404140-145447686 (+)
DBA/2J	MGP_DBA2J_G0028737	protein coding gene	Chr4:131416235-131445393 (+)
FVB/NJ	MGP_FVBNJ_G0028704	protein coding gene	Chr4:130307736-130342147 (+)
LP/J	MGP_LPJ_G0028836	protein coding gene	Chr4:136836724-136883671 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028730	protein coding gene	Chr4:149895710-149927181 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029388	protein coding gene	Chr4:135191421-135222658 (+)
PWK/PhJ	MGP_PWKPhJ_G0027775	protein coding gene	Chr4:128144135-128174386 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027601	protein coding gene	Chr4:131001682-131037486 (+)
WSB/EiJ	MGP_WSBEiJ_G0028133	protein coding gene	Chr4:135347321-135383791 (+)

Human Ortholog

PAFAH2, platelet activating factor acetylhydrolase 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PAFAH2, platelet activating factor acetylhydrolase 2
Synonyms

HSD-PLA2
Links

HGNC:8579

NCBI Gene ID: 5051

neXtProt AC: NX_Q99487

UniProt: Q99487
Chr Location

1p36.11; chr1:25959767-25998117 (-) GRCh38

MGI Vertebrate Homology

Pafah2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PAFAH2
Protein SuperFamily

PAF_acetylhydrolase
Gene Tree

Pafah2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

2
Gene trapped

12
Radiation induced

1
Targeted

2
Genomic Mutations

4 involving Pafah2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased sensitivity to hepatic injury.

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

67
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pafah2

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All Sequences

78
RefSeq

20
UniProt

5
CCDS

CCDS18771.1, CCDS71490.1

Ensembl

ENSMUSG00000037366 (Evidence)
NCBI Gene

100163

			Length	Strain/Species	Flank
genomic	100163	NCBI Gene Model \| MGI Sequence Detail	31093	C57BL/6J	± kb
transcript	NM_001285872	RefSeq \| MGI Sequence Detail	3194	C57BL/6
polypeptide	Q8VDG7	UniProt \| EBI \| MGI Sequence Detail	390	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000012230 platelet-activating factor acetylhydrolase 2, cytoplasmic

(term hierarchy)
EC

2.3.1.149, 3.1.1.47
InterPro Domains

IPR029058 Alpha/Beta hydrolase fold

IPR016715 Platelet-activating factor acetylhydrolase-like, eukaryote

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All nucleic 68

cDNA 67

Primer pair 1

Microarray probesets 4

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MGI:1919176

Summaries

All 39

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11

TSS for Pafah2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39557	Chr4:134123670-134123720 (+)	64 bp
Tssr39558	Chr4:134124617-134124637 (+)	996 bp
Tssr39559	Chr4:134124691-134124711 (+)	1,070 bp
Tssr39560	Chr4:134128614-134128636 (+)	4,994 bp
Tssr39561	Chr4:134128920-134128941 (+)	5,300 bp
Tssr39562	Chr4:134128970-134128985 (+)	5,347 bp
Tssr39563	Chr4:134129486-134129501 (+)	5,863 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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