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Phactr4 Gene Detail
Summary
  • Symbol
    Phactr4
  • Name
    phosphatase and actin regulator 4
  • Synonyms
    3110001B12Rik, C330013F19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140327
    NCBI Gene: 100169
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:132083233-132149765 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 65.24 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1831 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140327
 protein coding gene Chr4:132083233-132149800 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028870
 protein coding gene Chr4:134502420-134575985 (-)
A/J MGP_AJ_G0028829
 protein coding gene Chr4:128912437-128980223 (-)
AKR/J MGP_AKRJ_G0028782
 protein coding gene Chr4:132531688-132600667 (-)
BALB/cJ MGP_BALBcJ_G0028852
 protein coding gene Chr4:129524467-129591549 (-)
C3H/HeJ MGP_C3HHeJ_G0028566
 protein coding gene Chr4:132794308-132865342 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029294
 protein coding gene Chr4:139352416-139431054 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026565
 protein coding gene Chr4:121988336-122060793 (-)
CAST/EiJ MGP_CASTEiJ_G0027999
 protein coding gene Chr4:130869392-130942261 (-)
CBA/J MGP_CBAJ_G0028532
 protein coding gene Chr4:142926505-143005329 (-)
DBA/2J MGP_DBA2J_G0028681
 protein coding gene Chr4:129335299-129403106 (-)
FVB/NJ MGP_FVBNJ_G0028648
 protein coding gene Chr4:128183999-128254211 (-)
LP/J MGP_LPJ_G0028782
 protein coding gene Chr4:134659398-134727264 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028674
 protein coding gene Chr4:147517859-147605700 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029332
 protein coding gene Chr4:132937802-133013923 (-)
PWK/PhJ MGP_PWKPhJ_G0027720
 protein coding gene Chr4:126016411-126085280 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027546
 protein coding gene Chr4:128809562-128878777 (-)
WSB/EiJ MGP_WSBEiJ_G0028079
 protein coding gene Chr4:133121414-133195377 (-)



Homology
more
  • Human Ortholog
    PHACTR4, phosphatase and actin regulator 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PHACTR4, phosphatase and actin regulator 4
  • Synonyms
    PPP1R124
  • Links
    NCBI Gene ID: 65979
    neXtProt AC: NX_Q8IZ21
    UniProt: Q8IZ21

  • Chr Location
    1p35.3; chr1:28369582-28500364 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic and neonatal lethality, exencephaly, neural tube defects, coloboma, and altered cell cycles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    783
  • Tissues
    53
  • cDNA Data
    10
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 100169 NCBI Gene Model | MGI Sequence Detail 66533 C57BL/6J ±  kb
    transcript NM_175306 RefSeq | MGI Sequence Detail 4579 C57BL/6  
    polypeptide Q501J7 UniProt | EBI | MGI Sequence Detail 694 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917603, MGI:2140580, MGI:2140711
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:48268 Kasarskis A, et al., A phenotype-based screen for embryonic lethal mutations in the mouse. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7485-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory