About   Help   FAQ
Zfand2a Gene Detail
Summary
  • Symbol
    Zfand2a
  • Name
    zinc finger, AN1-type domain 2A
  • Synonyms
    Airap
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140729
    NCBI Gene: 100494
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:139456971-139470246 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 78.68 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    586 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140729
protein coding gene Chr5:139456966-139470304 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030286
protein coding gene Chr5:144455777-144470099 (-)
A/J MGP_AJ_G0030255
protein coding gene Chr5:138333698-138346996 (-)
AKR/J MGP_AKRJ_G0030187
protein coding gene Chr5:142644073-142657383 (-)
BALB/cJ MGP_BALBcJ_G0030272
protein coding gene Chr5:139575821-139589474 (-)
C3H/HeJ MGP_C3HHeJ_G0029983
protein coding gene Chr5:143418110-143431436 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030717
protein coding gene Chr5:149782209-149795532 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027935
protein coding gene Chr5:132193405-132206667 (-)
CAST/EiJ MGP_CASTEiJ_G0029388
protein coding gene Chr5:142830533-142846290 (-)
CBA/J MGP_CBAJ_G0029953
protein coding gene Chr5:155954831-155971152 (-)
DBA/2J MGP_DBA2J_G0030103
protein coding gene Chr5:138141182-138154724 (-)
FVB/NJ MGP_FVBNJ_G0030058
protein coding gene Chr5:137254431-137270610 (-)
LP/J MGP_LPJ_G0030189
protein coding gene Chr5:145063818-145078731 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030089
protein coding gene Chr5:158612390-158625683 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030757
protein coding gene Chr5:142455960-142470201 (-)
PWK/PhJ MGP_PWKPhJ_G0029103
protein coding gene Chr5:137147592-137160915 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028939
protein coding gene Chr5:140139306-140152152 (-)
WSB/EiJ MGP_WSBEiJ_G0029462
protein coding gene Chr5:143222575-143235874 (-)



Homology
more
  • Human Ortholog
    ZFAND2A, zinc finger AN1-type containing 2A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZFAND2A, zinc finger AN1-type containing 2A
  • Synonyms
    AIRAP
  • Links
    NCBI Gene ID: 90637
    neXtProt AC: NX_Q8N6M9
    UniProt: Q8N6M9

  • Chr Location
    7p22.3; chr7:1148850-1160759 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mouse embryonic fibroblasts accumulate more polyubiquitylated proteins than wild-type cells and display higher levels of stress when exposed to arsenite, while isolated proteasomes are relatively impaired in substrate degradation in vitro.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 100494 NCBI Gene Model | MGI Sequence Detail 13276 C57BL/6J ±  kb
transcript NM_133349 RefSeq | MGI Sequence Detail 3191 C57BL/6  
polypeptide Q9JII7 UniProt | EBI | MGI Sequence Detail 171 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 64
    cDNA 64

    Microarray probesets 6
Other
Accession IDs
less
MGI:2141030
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory