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Slc15a4 Gene Detail
Summary
  • Symbol
    Slc15a4
  • Name
    solute carrier family 15, member 4
  • Synonyms
    C130069N12Rik, PHT1, PTR4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140796
    NCBI Gene: 100561
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:127672728-127709961 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 66.00 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1149 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140796
 protein coding gene Chr5:127668795-127710356 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030116
 protein coding gene Chr5:131549823-131587705 (-)
A/J MGP_AJ_G0030083
 protein coding gene Chr5:126039125-126077221 (-)
AKR/J MGP_AKRJ_G0030017
 protein coding gene Chr5:130132110-130175259 (-)
BALB/cJ MGP_BALBcJ_G0030093
 protein coding gene Chr5:127379969-127419026 (-)
C3H/HeJ MGP_C3HHeJ_G0029810
 protein coding gene Chr5:130716983-130754072 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030546
 protein coding gene Chr5:136609166-136648462 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027771
 protein coding gene Chr5:120489970-120527014 (-)
CAST/EiJ MGP_CASTEiJ_G0029219
 protein coding gene Chr5:129900642-129961515 (-)
CBA/J MGP_CBAJ_G0029780
 protein coding gene Chr5:141963377-142002123 (-)
DBA/2J MGP_DBA2J_G0029930
 protein coding gene Chr5:126037093-126074404 (-)
FVB/NJ MGP_FVBNJ_G0029886
 protein coding gene Chr5:125086757-125123976 (-)
LP/J MGP_LPJ_G0030019
 protein coding gene Chr5:132076058-132114827 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029917
 protein coding gene Chr5:145392211-145437730 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030587
 protein coding gene Chr5:129788050-129826204 (-)
PWK/PhJ MGP_PWKPhJ_G0028933
 protein coding gene Chr5:124885902-124943938 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028770
 protein coding gene Chr5:127322693-127379444 (-)
WSB/EiJ MGP_WSBEiJ_G0029293
 protein coding gene Chr5:130454729-130491517 (-)



Homology
more
  • Human Ortholog
    SLC15A4, solute carrier family 15 member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC15A4, solute carrier family 15 member 4
  • Synonyms
    FP12591, PHT1, PTR4
  • Links
    NCBI Gene ID: 121260
    neXtProt AC: NX_Q8N697
    UniProt: Q8N697

  • Chr Location
    12q24.33; chr12:128793194-128823958 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation display abrogation of both Toll-like receptor (TLR)-induced type I IFN and proinflammatory cytokine production by plasmacytoid dendritic cells. Mice homozygous for a knock-out allele show impaired TLR9-and NOD1-mediated cytokine production and decreased susceptibility to DSS-induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    10
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029416 Ensembl Gene Model | MGI Sequence Detail 37234 C57BL/6J ±  kb
    transcript ENSMUST00000031367 Ensembl | MGI Sequence Detail 2732 Not Applicable  
    polypeptide ENSMUSP00000031367 Ensembl | MGI Sequence Detail 574 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000014943 solute carrier family 15 member 4
      (term hierarchy)
    • InterPro Domains
      IPR036259 MFS transporter superfamily
      IPR000109 Proton-dependent oligopeptide transporter family
      IPR018456 PTR2 family proton/oligopeptide symporter, conserved site
    • GlyGen
      Q91W98 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141246
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 1
      Gene Ontology 16
      Phenotypes 25
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:349734 Rimann I, et al., The solute carrier SLC15A4 is required for optimal trafficking of nucleic acid-sensing TLRs and ligands to endolysosomes. Proc Natl Acad Sci U S A. 2022 Apr 5;119(14):e2200544119
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory