Hsd17b13 MGI Mouse Gene Detail - MGI:2140804 - hydroxysteroid (17-beta) dehydrogenase 13

Symbol

Hsd17b13
Name

hydroxysteroid (17-beta) dehydrogenase 13
Synonyms

Pan1b

Feature Type

protein coding gene
IDs

MGI:2140804
NCBI Gene: 243168
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:104103308-104125254 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 50.46 cM
Mapping Data

1 experiment

SNPs within 2kb

881 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2140804	protein coding gene	Chr5:104103306-104125276 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029805	protein coding gene	Chr5:105618374-105643621 (-)
A/J	MGP_AJ_G0029769	protein coding gene	Chr5:101642565-101665927 (-)
AKR/J	MGP_AKRJ_G0029717	protein coding gene	Chr5:104925794-104950012 (-)
BALB/cJ	MGP_BALBcJ_G0029781	protein coding gene	Chr5:102706371-102728101 (-)
C3H/HeJ	MGP_C3HHeJ_G0029504	protein coding gene	Chr5:105330406-105357701 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030236	protein coding gene	Chr5:109925756-109950577 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027471	protein coding gene	Chr5:96781489-96804909 (-)
CAST/EiJ	MGP_CASTEiJ_G0028915	protein coding gene	Chr5:104035585-104064808 (-)
CBA/J	MGP_CBAJ_G0029474	protein coding gene	Chr5:113756203-113779665 (-)
DBA/2J	MGP_DBA2J_G0029618	protein coding gene	Chr5:101835777-101857705 (-)
FVB/NJ	MGP_FVBNJ_G0029577	protein coding gene	Chr5:100634793-100656290 (-)
LP/J	MGP_LPJ_G0029706	protein coding gene	Chr5:106182365-106207096 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029606	protein coding gene	Chr5:118695233-118720753 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030269	protein coding gene	Chr5:104461428-104488921 (-)
PWK/PhJ	MGP_PWKPhJ_G0028633	protein coding gene	Chr5:100291934-100315448 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028468	protein coding gene	Chr5:102121054-102144695 (-)
WSB/EiJ	MGP_WSBEiJ_G0028993	protein coding gene	Chr5:104835241-104858847 (-)

Human Ortholog

HSD17B13, hydroxysteroid 17-beta dehydrogenase 13

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HSD17B13, hydroxysteroid 17-beta dehydrogenase 13
Synonyms

FLDP, HMFN0376, NIIL497, SCDR9, SDR16C3
Links

HGNC:18685

NCBI Gene ID: 345275

neXtProt AC: NX_Q7Z5P4

UniProt: Q7Z5P4
Chr Location

4q22.1; chr4:87303789-87322886 (-) GRCh38

MGI Vertebrate Homology

Hsd17b13 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: HSD17B13
Gene Tree

Hsd17b13

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Phenotype Summary

10 phenotypes from 1 allele in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

1
Spontaneous

1
Targeted

2
Genomic Mutations

3 involving Hsd17b13
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a null allele exhibit hepatic steatosis, increased liver triglyceride levels, increased lipogenesis, decreased fatty acid beta-oxidaton, and liver inflammation.

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All GO Annotations

10
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

22
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hsd17b13

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All Sequences

40
RefSeq

4
UniProt

2
CCDS

CCDS19480.1, CCDS51576.1

Ensembl

ENSMUSG00000034528 (Evidence)
NCBI Gene

243168

			Length	Strain/Species	Flank
genomic	243168	NCBI Gene Model \| MGI Sequence Detail	21947	C57BL/6J	± kb
transcript	NM_198030	RefSeq \| MGI Sequence Detail	1730	C57BL/6
polypeptide	Q8VCR2	UniProt \| EBI \| MGI Sequence Detail	304	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008777 17-beta-hydroxysteroid dehydrogenase 13

(term hierarchy)
EC

1.1.1.-, 1.1.1.105, 1.1.1.62
InterPro Domains

IPR036291 NAD(P)-binding domain superfamily

IPR002347 Short-chain dehydrogenase/reductase SDR
GlyGen

Q8VCR2 1 site, 1 O-linked glycan (1 site)

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All nucleic 22

cDNA 22

Microarray probesets 4

Summaries

All 40

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 14
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:333290 Ma Y, et al., 17-Beta Hydroxysteroid Dehydrogenase 13 Deficiency Does Not Protect Mice From Obesogenic Diet Injury. Hepatology. 2021 May;73(5):1701-1716

TSS for Hsd17b13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr52177	Chr5:104125270-104125281 (-)	-22 bp
Tssr52176	Chr5:104125226-104125269 (-)	6 bp
Tssr52175	Chr5:104125205-104125222 (-)	40 bp
Tssr52174	Chr5:104118708-104118714 (-)	6,543 bp
Tssr52173	Chr5:104114907-104114912 (-)	10,344 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24