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Nsun5 Gene Detail
Summary
  • Symbol
    Nsun5
  • Name
    NOL1/NOP2/Sun domain family, member 5
  • Synonyms
    9830109N13Rik, Nol1r, Wbscr20a
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140844
    NCBI Gene: 100609
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:135398807-135405659 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 75.16 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    231 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140844
 protein coding gene Chr5:135398784-135405661 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030181
 protein coding gene Chr5:139892184-139900358 (+)
A/J MGP_AJ_G0030149
 protein coding gene Chr5:133905058-133911910 (+)
AKR/J MGP_AKRJ_G0030082
 protein coding gene Chr5:138257613-138264465 (+)
BALB/cJ MGP_BALBcJ_G0030159
 protein coding gene Chr5:135259988-135266832 (+)
C3H/HeJ MGP_C3HHeJ_G0029875
 protein coding gene Chr5:138824521-138831412 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030612
 protein coding gene Chr5:145116537-145123414 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027835
 protein coding gene Chr5:128203096-128209870 (+)
CAST/EiJ MGP_CASTEiJ_G0029284
 protein coding gene Chr5:138233208-138240746 (+)
CBA/J MGP_CBAJ_G0029845
 protein coding gene Chr5:150810292-150817143 (+)
DBA/2J MGP_DBA2J_G0029996
 protein coding gene Chr5:133815007-133821859 (+)
FVB/NJ MGP_FVBNJ_G0029951
 protein coding gene Chr5:132942351-132949219 (+)
LP/J MGP_LPJ_G0030084
 protein coding gene Chr5:140347554-140354393 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029983
 protein coding gene Chr5:153804842-153813000 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030652
 protein coding gene Chr5:138001584-138009297 (+)
PWK/PhJ MGP_PWKPhJ_G0028999
 protein coding gene Chr5:132848711-132855503 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028834
 protein coding gene Chr5:135564631-135572260 (+)
WSB/EiJ MGP_WSBEiJ_G0029358
 protein coding gene Chr5:138755796-138764102 (+)



Homology
more
  • Human Ortholog
    NSUN5, NOP2/Sun RNA methyltransferase 5
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NSUN5, NOP2/Sun RNA methyltransferase 5
  • Synonyms
    NOL1, NOL1R, NSUN5A, p120, p120(NOL1), WBSCR20, WBSCR20A
  • Links
    NCBI Gene ID: 55695
    neXtProt AC: NX_Q96P11
    UniProt: Q96P11

  • Chr Location
    7q11.23; chr7:73302516-73308826 (-)  GRCh38
  • Human Ortholog
    NSUN5P1, NSUN5 pseudogene 1
  • Synonyms
    NSUN5B, WBSCR20B
  • Links
    NCBI Gene ID: 155400
    UniProt: Q3KNT7

  • Chr Location
    7q11.23; chr7:75410322-75416794 (+)  GRCh38
  • Human Ortholog
    NSUN5P2, NSUN5 pseudogene 2
  • Synonyms
    NOL1R2, NSUN5C, WBSCR20B, WBSCR20C
  • Links
    NCBI Gene ID: 260294
    UniProt: Q63ZY6

  • Chr Location
    7q11.23; chr7:72947581-72954790 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired spatial working memory and learning with decreased LTP and reduced OPC proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    838
  • Tissues
    87
  • cDNA Data
    9
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000916 Ensembl Gene Model | MGI Sequence Detail 6853 C57BL/6J ±  kb
    transcript ENSMUST00000000940 Ensembl | MGI Sequence Detail 2243 Not Applicable  
    polypeptide ENSMUSP00000000940 Ensembl | MGI Sequence Detail 465 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000029655 28S rRNA (cytosine-C(5))-methyltransferase
      (term hierarchy)
    • EC
      2.1.1.-
    • InterPro Domains
      IPR049561 NOL1/NOP2/NSUN 5/7, ferredoxin-like domain
      IPR048889 NSUN5/RCM1, N-terminal domain
      IPR023267 RNA (C5-cytosine) methyltransferase
      IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
      IPR049560 SAM-dependent methyltransferase RsmB-F/NOP2-type, catalytic core
      IPR001678 SAM-dependent methyltransferase RsmB-F/NOP2-type domain
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 2
      cDNA 9
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2157794
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 16
    • Earliest
      J:73830 DeSilva U, et al., Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome. Genome Res. 2002 Jan;12(1):3-15
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory