Mapre3 MGI Mouse Gene Detail - MGI:2140967 - microtubule-associated protein, RP/EB family, member 3

Symbol

Mapre3
Name

microtubule-associated protein, RP/EB family, member 3
Synonyms

EB3

Feature Type

protein coding gene
IDs

MGI:2140967
NCBI Gene: 100732
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr5:30972075-31023447 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 16.90 cM
Mapping Data

1 experiment

SNPs within 2kb

1474 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2140967	protein coding gene	Chr5:30971985-31023450 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029396	protein coding gene	Chr5:28769219-28821618 (+)
A/J	MGP_AJ_G0029362	protein coding gene	Chr5:27834331-27887522 (+)
AKR/J	MGP_AKRJ_G0029313	protein coding gene	Chr5:28983034-29039641 (+)
BALB/cJ	MGP_BALBcJ_G0029373	protein coding gene	Chr5:28357357-28409565 (+)
C3H/HeJ	MGP_C3HHeJ_G0029094	protein coding gene	Chr5:28977568-29031241 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029826	protein coding gene	Chr5:30548029-30600014 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027064	protein coding gene	Chr5:25316469-25365298 (+)
CAST/EiJ	MGP_CASTEiJ_G0028505	protein coding gene	Chr5:28071615-28124892 (+)
CBA/J	MGP_CBAJ_G0029062	protein coding gene	Chr5:31119011-31174902 (+)
DBA/2J	MGP_DBA2J_G0029211	protein coding gene	Chr5:28018932-28069750 (+)
FVB/NJ	MGP_FVBNJ_G0029169	protein coding gene	Chr5:27431583-27481735 (+)
LP/J	MGP_LPJ_G0029296	protein coding gene	Chr5:29232152-29288687 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029198	protein coding gene	Chr5:32013060-32066453 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029860	protein coding gene	Chr5:28486551-28539041 (+)
PWK/PhJ	MGP_PWKPhJ_G0028229	protein coding gene	Chr5:27131833-27185397 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028082	protein coding gene	Chr5:28322177-28326483 (-)
WSB/EiJ	MGP_WSBEiJ_G0028585	protein coding gene	Chr5:28551329-28603724 (+)

Human Ortholog

MAPRE3, microtubule associated protein RP/EB family member 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAPRE3, microtubule associated protein RP/EB family member 3
Synonyms

EB3, EBF3, EBF3-S, RP3
Links

HGNC:6892

NCBI Gene ID: 22924

neXtProt AC: NX_Q9UPY8

UniProt: Q9UPY8
Chr Location

2p23.3; chr2:26970637-27027219 (+) GRCh38

MGI Vertebrate Homology

Mapre3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MAPRE3
Gene Tree

Mapre3

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

2
Gene trapped

2
Radiation induced

2
Spontaneous

1
Targeted

4
Genomic Mutations

5 involving Mapre3
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional allele activated in endothelial cells fail to exhibit F2r agonist-induced vascular hyper-permeability.

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All GO Annotations

34
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5
Literature Summary

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mapre3

ZFIN mapre3b

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All Sequences

72
RefSeq

14
UniProt

4
CCDS

CCDS19163.1, CCDS80240.1

Ensembl

ENSMUSG00000029166 (Evidence)
NCBI Gene

100732

			Length	Strain/Species	Flank
genomic	100732	NCBI Gene Model \| MGI Sequence Detail	51373	C57BL/6J	± kb
transcript	NM_001425743	RefSeq \| MGI Sequence Detail	1952	C57BL/6
polypeptide	Q6PER3	UniProt \| EBI \| MGI Sequence Detail	281	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010172 microtubule-associated protein RP/EB family member 3

(term hierarchy)
InterPro Domains

IPR001715 Calponin homology domain

IPR036872 CH domain superfamily

IPR004953 EB1, C-terminal

IPR036133 EB1, C-terminal domain superfamily

IPR027328 Microtubule-associated protein RP/EB
GlyGen

Q6PER3 1 site, 1 N-linked glycan (1 site)

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All nucleic 5

cDNA 5

Microarray probesets 4

Summaries

All 61

Developmental Gene Expression 4

Diseases 1

Gene Ontology 7

Phenotypes 29
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mapre3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45622	Chr5:30971915-30971961 (+)	-137 bp
Tssr45623	Chr5:30972066-30972120 (+)	18 bp
Tssr45624	Chr5:30972128-30972144 (+)	61 bp
Tssr45625	Chr5:30972393-30972404 (+)	324 bp
Tssr45626	Chr5:31011132-31011138 (+)	39,060 bp
Tssr45627	Chr5:31011140-31011145 (+)	39,068 bp
Tssr45628	Chr5:31011152-31011192 (+)	39,097 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24