Mlxip MGI Mouse Gene Detail - MGI:2141183

Symbol

Mlxip
Name

MLX interacting protein
Synonyms

bHLHe36, Mir, mKIAA0867, Mondoa

Feature Type

protein coding gene
IDs

MGI:2141183
NCBI Gene: 208104
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:123532861-123595995 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 62.95 cM
Mapping Data

1 experiment

SNPs within 2kb

1353 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2141183	protein coding gene	Chr5:123532438-123595998 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030070	protein coding gene	Chr5:127134789-127197085 (+)
A/J	MGP_AJ_G0030035	protein coding gene	Chr5:121855601-121919537 (+)
AKR/J	MGP_AKRJ_G0029971	protein coding gene	Chr5:125784712-125856014 (+)
BALB/cJ	MGP_BALBcJ_G0030046	protein coding gene	Chr5:123180612-123251959 (+)
C3H/HeJ	MGP_C3HHeJ_G0029763	protein coding gene	Chr5:126399872-126469548 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030499	protein coding gene	Chr5:132047248-132115319 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027725	protein coding gene	Chr5:116393548-116456398 (+)
CAST/EiJ	MGP_CASTEiJ_G0029172	protein coding gene	Chr5:125490233-125558283 (+)
CBA/J	MGP_CBAJ_G0029733	protein coding gene	Chr5:137232557-137311644 (+)
DBA/2J	MGP_DBA2J_G0029883	protein coding gene	Chr5:121872345-121934882 (+)
FVB/NJ	MGP_FVBNJ_G0029839	protein coding gene	Chr5:120896731-120964431 (+)
LP/J	MGP_LPJ_G0029972	protein coding gene	Chr5:127661451-127733618 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029870	protein coding gene	Chr5:140875490-140947030 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030540	protein coding gene	Chr5:125373230-125441881 (+)
PWK/PhJ	MGP_PWKPhJ_G0028886	protein coding gene	Chr5:120672861-120738597 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028723	protein coding gene	Chr5:123041421-123110934 (+)
WSB/EiJ	MGP_WSBEiJ_G0029247	protein coding gene	Chr5:126023181-126096312 (+)

Human Ortholog

MLXIP, MLX interacting protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MLXIP, MLX interacting protein
Synonyms

bHLHe36, MIR, MONDOA
Links

HGNC:17055

NCBI Gene ID: 22877

neXtProt AC: NX_Q9HAP2

UniProt: Q9HAP2
Chr Location

12q24.31; chr12:122078756-122147344 (+) GRCh38

MGI Vertebrate Homology

Mlxip stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MLXIP
Gene Tree

Mlxip

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

2
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Mlxip
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display metabolic and performance abnormalities in response to mild exercise and improved sprint exercise performance.

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

770
Tissues

39
cDNA Data

97
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MLXIP

Xenbase mlxip

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All Sequences

52
RefSeq

5
UniProt

6
CCDS

CCDS19662.1, CCDS39268.1

Ensembl

ENSMUSG00000038342 (Evidence)
NCBI Gene

208104

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038342	Ensembl Gene Model \| MGI Sequence Detail	63135	C57BL/6J	± kb
transcript	ENSMUST00000068237	Ensembl \| MGI Sequence Detail	7303	Not Applicable
polypeptide	ENSMUSP00000064943	Ensembl \| MGI Sequence Detail	917	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000010459 MLX-interacting protein

(term hierarchy)
InterPro Domains

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
GlyGen

Q2VPU4 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 99

Genomic 2

cDNA 97

Microarray probesets 3

Summaries

All 47

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:324848 Yamamoto-Imoto H, et al., Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis. Cell Rep. 2022 Mar 1;38(9):110444

TSS for Mlxip:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48790	Chr5:123532793-123532802 (+)	-63 bp
Tssr48791	Chr5:123532845-123532889 (+)	6 bp
Tssr48793	Chr5:123553001-123553008 (+)	20,144 bp
Tssr48794	Chr5:123567112-123567118 (+)	34,254 bp
Tssr48795	Chr5:123580353-123580367 (+)	47,499 bp
Tssr48796	Chr5:123583860-123583875 (+)	51,007 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24