Nup205 MGI Mouse Gene Detail - MGI:2141625

Symbol

Nup205
Name

nucleoporin 205
Synonyms

3830404O05Rik, mKIAA0225

Feature Type

protein coding gene
IDs

MGI:2141625
NCBI Gene: 70699
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr6:35154551-35224534 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 15.24 cM, cytoband B1
Mapping Data

3 experiments

SNPs within 2kb

1691 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2141625	protein coding gene	Chr6:35154356-35224534 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030569	protein coding gene	Chr6:33315317-33391366 (+)
A/J	MGP_AJ_G0030542	protein coding gene	Chr6:31872149-31942978 (+)
AKR/J	MGP_AKRJ_G0030469	protein coding gene	Chr6:32946420-33016253 (+)
BALB/cJ	MGP_BALBcJ_G0030552	protein coding gene	Chr6:32053674-32128834 (+)
C3H/HeJ	MGP_C3HHeJ_G0030265	protein coding gene	Chr6:32909759-32986535 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031006	protein coding gene	Chr6:34139948-34213923 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028218	protein coding gene	Chr6:29956050-30026785 (+)
CAST/EiJ	MGP_CASTEiJ_G0029667	protein coding gene	Chr6:32744541-32828646 (+)
CBA/J	MGP_CBAJ_G0030243	protein coding gene	Chr6:35470351-35560129 (+)
DBA/2J	MGP_DBA2J_G0030387	protein coding gene	Chr6:31748677-31818643 (+)
FVB/NJ	MGP_FVBNJ_G0030341	protein coding gene	Chr6:31545340-31617293 (+)
LP/J	MGP_LPJ_G0030474	protein coding gene	Chr6:33418915-33490952 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030377	protein coding gene	Chr6:37771197-37851130 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031036	protein coding gene	Chr6:32828598-32899704 (+)
PWK/PhJ	MGP_PWKPhJ_G0029381	protein coding gene	Chr6:31380241-31452204 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029217	protein coding gene	Chr6:32511719-32585387 (+)
WSB/EiJ	MGP_WSBEiJ_G0029743	protein coding gene	Chr6:32772894-32846633 (+)

Human Ortholog

NUP205, nucleoporin 205

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NUP205, nucleoporin 205
Synonyms

C7orf14, NPHS13
Links

HGNC:18658

NCBI Gene ID: 23165

neXtProt AC: NX_Q92621

UniProt: Q92621
Chr Location

7q33; chr7:135557917-135648757 (+) GRCh38

MGI Vertebrate Homology

Nup205 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NUP205
Gene Tree

Nup205

Diseases

1 with human NUP205 associations

				Human Disease	Mouse Models
				nephrotic syndrome type 13 IDs nephrotic syndrome type 13 DOID:0080381 OMIM:616893

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
1 images
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Endonuclease-mediated

2
Gene trapped

26
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

103 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show complete embryonic lethality before implantation. In vitro, blastocysts fail to hatch from the zona pellucida and die after 3 days in culture.

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All GO Annotations

9
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

16
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nup205

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All Sequences

70
RefSeq

11
UniProt

10
CCDS

CCDS57418.1

Ensembl

ENSMUSG00000038759 (Evidence)
NCBI Gene

70699

			Length	Strain/Species	Flank
genomic	70699	NCBI Gene Model \| MGI Sequence Detail	69984	C57BL/6J	± kb
transcript	NM_027513	RefSeq \| MGI Sequence Detail	6244	C57BL/6
polypeptide	NP_081789	RefSeq \| MGI Sequence Detail	2008	C57BL/6

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UniProt

10 Sequences
InterPro Domains

IPR021827 Nucleoporin Nup186/Nup192/Nup205
GlyGen

B9EJ54 1 site, 1 N-linked glycan (1 site)

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All nucleic 17

cDNA 17

Microarray probesets 6

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MGI:1917949

Summaries

All 37

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nup205:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr55575	Chr6:35154321-35154361 (+)	-210 bp
Tssr55576	Chr6:35154545-35154562 (+)	3 bp
Tssr55577	Chr6:35154653-35154693 (+)	122 bp
Tssr55578	Chr6:35154749-35154761 (+)	204 bp
Tssr55579	Chr6:35154776-35154795 (+)	235 bp
Tssr55580	Chr6:35154830-35154871 (+)	300 bp
Tssr55581	Chr6:35155039-35155049 (+)	493 bp
Tssr55582	Chr6:35155054-35155074 (+)	513 bp
Tssr55583	Chr6:35162174-35162179 (+)	7,626 bp
Tssr55584	Chr6:35182366-35182380 (+)	27,822 bp
Tssr55585	Chr6:35213447-35213491 (+)	58,918 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24