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Atf5 Gene Detail
Summary
  • Symbol
    Atf5
  • Name
    activating transcription factor 5
  • Synonyms
    AFTA, Atf7, Atfx, ODA-10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141857
    NCBI Gene: 107503
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44461680-44466082 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    168 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141857
 protein coding gene Chr7:44461680-44466082 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032178
 protein coding gene Chr7:45017840-45022167 (-)
A/J MGP_AJ_G0032157
 protein coding gene Chr7:44176037-44180364 (-)
AKR/J MGP_AKRJ_G0032093
 protein coding gene Chr7:45389967-45394310 (-)
BALB/cJ MGP_BALBcJ_G0032169
 protein coding gene Chr7:44174604-44178933 (-)
C3H/HeJ MGP_C3HHeJ_G0031885
 protein coding gene Chr7:45889401-45894200 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032661
 protein coding gene Chr7:47281743-47286086 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029675
 protein coding gene Chr7:46746488-46750777 (-)
CAST/EiJ MGP_CASTEiJ_G0031213
 protein coding gene Chr7:37263048-37267398 (-)
CBA/J MGP_CBAJ_G0031849
 protein coding gene Chr7:48835232-48839559 (-)
DBA/2J MGP_DBA2J_G0032007
 protein coding gene Chr7:43846907-43851234 (-)
FVB/NJ MGP_FVBNJ_G0031958
 protein coding gene Chr7:43621756-43626381 (-)
LP/J MGP_LPJ_G0032085
 protein coding gene Chr7:45702980-45707347 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031995
 protein coding gene Chr7:47571244-47576390 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032677
 protein coding gene Chr7:44613597-44618162 (-)
PWK/PhJ MGP_PWKPhJ_G0030936
 protein coding gene Chr7:37210801-37215249 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030773
 protein coding gene Chr7:32617126-32621471 (-)
WSB/EiJ MGP_WSBEiJ_G0031330
 protein coding gene Chr7:45088818-45093680 (-)



Homology
more
  • Human Ortholog
    ATF5, activating transcription factor 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATF5, activating transcription factor 5
  • Synonyms
    ATFX, HMFN0395
  • Links
    NCBI Gene ID: 22809
    neXtProt AC: NX_Q9Y2D1
    UniProt: Q9Y2D1

  • Chr Location
    19q13.33; chr19:49928702-49933935 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial neonatal and postnatal lethality, absence of gastric milk in some mice, decreased body weight in mice that survive and loss of mature olfactory sensory neurons with increased apoptosis in olfactory epithelium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1111
  • Tissues
    218
  • cDNA Data
    141
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107503 NCBI Gene Model | MGI Sequence Detail 4403 C57BL/6J ±  kb
    transcript NR_033136 RefSeq | MGI Sequence Detail 1833 C57BL/6  
    polypeptide O70191 UniProt | EBI | MGI Sequence Detail 283 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 148
      cDNA 142
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1446, MGI:1858966, MGI:88097
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 22
      Gene Ontology 12
      Phenotypes 15
    • Earliest
      J:2973 Nishizawa M, et al., cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein. FEBS Lett. 1992 Mar 24;299(1):36-8
    • Latest
      J:345326 Chen XZ, et al., TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m(7)G methylation of ATF5 mRNA. Cell Death Differ. 2023 Jul;30(7):1786-1798
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory