Ric8a MGI Mouse Gene Detail - MGI:2141866 - RIC8 guanine nucleotide exchange factor A

Symbol

Ric8a
Name

RIC8 guanine nucleotide exchange factor A
Synonyms

Ric8, RIC-8, synembryn

Feature Type

protein coding gene
IDs

MGI:2141866
NCBI Gene: 101489
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:140437310-140443644 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 86.06 cM
Mapping Data

1 experiment

SNPs within 2kb

229 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2141866	protein coding gene	Chr7:140436870-140444285 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033196	protein coding gene	Chr7:145994348-146000902 (+)
A/J	MGP_AJ_G0033178	protein coding gene	Chr7:141841045-141847818 (+)
AKR/J	MGP_AKRJ_G0033110	protein coding gene	Chr7:145727083-145733856 (+)
BALB/cJ	MGP_BALBcJ_G0033179	protein coding gene	Chr7:141567797-141575075 (+)
C3H/HeJ	MGP_C3HHeJ_G0032893	protein coding gene	Chr7:145485848-145492621 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033690	protein coding gene	Chr7:151331368-151338141 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030663	protein coding gene	Chr7:143050115-143056950 (+)
CAST/EiJ	MGP_CASTEiJ_G0032223	protein coding gene	Chr7:137782996-137789781 (+)
CBA/J	MGP_CBAJ_G0032865	protein coding gene	Chr7:156461649-156468422 (+)
DBA/2J	MGP_DBA2J_G0033018	protein coding gene	Chr7:139779061-139785834 (+)
FVB/NJ	MGP_FVBNJ_G0032970	protein coding gene	Chr7:139689219-139695992 (+)
LP/J	MGP_LPJ_G0033112	protein coding gene	Chr7:147492498-147500704 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033003	protein coding gene	Chr7:157129134-157135907 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033710	protein coding gene	Chr7:144713617-144720390 (+)
PWK/PhJ	MGP_PWKPhJ_G0031928	protein coding gene	Chr7:133047222-133054064 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031774	protein coding gene	Chr7:131532671-131539428 (+)
WSB/EiJ	MGP_WSBEiJ_G0032334	protein coding gene	Chr7:145633406-145640179 (+)

Human Ortholog

RIC8A, RIC8 guanine nucleotide exchange factor A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RIC8A, RIC8 guanine nucleotide exchange factor A
Synonyms

RIC8
Links

HGNC:29550

NCBI Gene ID: 60626

neXtProt AC: NX_Q9NPQ8

UniProt: Q9NPQ8
Chr Location

11p15.5; chr11:207708-215113 (+) GRCh38

MGI Vertebrate Homology

Ric8a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RIC8A
Gene Tree

Ric8a

less

Phenotype Summary

22 phenotypes from 3 alleles in 5 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Radiation induced

1
Targeted

7
Genomic Mutations

1 involving Ric8a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in lethality during gastrulation. Heterozygotes exhibit impaired spatial learning and increased anxiety.

less

All GO Annotations

37
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1014
Tissues

152
cDNA Data

115
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ric8a

ZFIN ric8a

less

All Sequences

65
RefSeq

2
UniProt

3
CCDS

CCDS21988.1

Ensembl

ENSMUSG00000025485 (Evidence)
NCBI Gene

101489

			Length	Strain/Species	Flank
genomic	101489	NCBI Gene Model \| MGI Sequence Detail	6335	C57BL/6J	± kb
transcript	NM_053194	RefSeq \| MGI Sequence Detail	2967	C57BL/6
polypeptide	Q3TIR3	UniProt \| EBI \| MGI Sequence Detail	530	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000013995 synembryn-A

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR019318 Guanine nucleotide exchange factor, Ric8

IPR008376 Synembryn

less

All nucleic 118

cDNA 116

Primer pair 2

Microarray probesets 3

Summaries

All 55

Developmental Gene Expression 10

Gene Ontology 10

Phenotypes 20
Earliest

J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ric8a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69854	Chr7:140436240-140436283 (+)	-1,048 bp
Tssr69855	Chr7:140436356-140436377 (+)	-943 bp
Tssr69856	Chr7:140436384-140436426 (+)	-905 bp
Tssr69857	Chr7:140436427-140436443 (+)	-875 bp
Tssr69858	Chr7:140436649-140436680 (+)	-645 bp
Tssr69859	Chr7:140437301-140437370 (+)	26 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24