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Ccp110 Gene Detail
Summary
  • Symbol
    Ccp110
  • Name
    centriolar coiled coil protein 110
  • Synonyms
    6330503K22Rik, CP110
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141942
    NCBI Gene: 101565
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:118311775-118336247 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 63.58 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    589 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141942
 protein coding gene Chr7:118311740-118336247 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032903
 protein coding gene Chr7:122574544-122605856 (+)
A/J MGP_AJ_G0032886
 protein coding gene Chr7:119457066-119481271 (+)
AKR/J MGP_AKRJ_G0032818
 protein coding gene Chr7:122512590-122539577 (+)
BALB/cJ MGP_BALBcJ_G0032891
 protein coding gene Chr7:119174304-119198987 (+)
C3H/HeJ MGP_C3HHeJ_G0032601
 protein coding gene Chr7:122405199-122430351 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033397
 protein coding gene Chr7:127468264-127492502 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030369
 protein coding gene Chr7:120893036-120917492 (+)
CAST/EiJ MGP_CASTEiJ_G0031929
 protein coding gene Chr7:114171354-114198861 (+)
CBA/J MGP_CBAJ_G0032574
 protein coding gene Chr7:131726718-131756998 (+)
DBA/2J MGP_DBA2J_G0032726
 protein coding gene Chr7:117492734-117517031 (+)
FVB/NJ MGP_FVBNJ_G0032679
 protein coding gene Chr7:117335893-117360188 (+)
LP/J MGP_LPJ_G0032820
 protein coding gene Chr7:124038409-124065339 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032711
 protein coding gene Chr7:133209608-133233577 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033417
 protein coding gene Chr7:121519376-121546376 (+)
PWK/PhJ MGP_PWKPhJ_G0031637
 protein coding gene Chr7:110396170-110421211 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031484
 protein coding gene Chr7:108234724-108260126 (+)
WSB/EiJ MGP_WSBEiJ_G0032042
 protein coding gene Chr7:122401624-122426243 (+)



Homology
more
  • Human Ortholog
    CCP110, centriolar coiled-coil protein 110
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCP110, centriolar coiled-coil protein 110
  • Synonyms
    Cep110, CP110
  • Links
    NCBI Gene ID: 9738
    neXtProt AC: NX_O43303
    UniProt: O43303

  • Chr Location
    16p12.3; chr16:19523811-19553408 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit pleiotropic phenotypes due to impaired sonic hedgehog (Shh) signaling and failure of primary cilia formation in multiple tissues.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    7
  • cDNA Data
    63
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033904 Ensembl Gene Model | MGI Sequence Detail 24473 C57BL/6J ±  kb
    transcript ENSMUST00000106557 Ensembl | MGI Sequence Detail 5073 Not Applicable  
    polypeptide ENSMUSP00000102167 Ensembl | MGI Sequence Detail 1004 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000030637 centriolar coiled-coil protein of 110 kDa
      (term hierarchy)
    • InterPro Domains
      IPR033207 Centriolar coiled-coil protein of 110kDa
    • GlyGen
      Q7TSH4 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 63
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142266, MGI:3034890
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 8
      Gene Ontology 17
      Phenotypes 5
    • Earliest
      J:66488 Feng Y, et al., LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome. Neuron. 2000 Dec;28(3):665-79
    • Latest
      J:326906 Song T, et al., ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis. EMBO Rep. 2022 May 4;23(5):e54090
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory