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Psip1 Gene Detail
Summary
  • Symbol
    Psip1
  • Name
    PC4 and SFRS1 interacting protein 1
  • Synonyms
    Psip2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142116
    NCBI Gene: 101739
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:83373917-83404696 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 39.46 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    726 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142116
 protein coding gene Chr4:83373917-83404700 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028404
 protein coding gene Chr4:83053693-83087932 (-)
A/J MGP_AJ_G0028365
 protein coding gene Chr4:80158834-80192639 (-)
AKR/J MGP_AKRJ_G0028314
 protein coding gene Chr4:82249774-82284690 (-)
BALB/cJ MGP_BALBcJ_G0028385
 protein coding gene Chr4:80390599-80425752 (-)
C3H/HeJ MGP_C3HHeJ_G0028100
 protein coding gene Chr4:82841946-82873857 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028824
 protein coding gene Chr4:86323591-86366856 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026124
 protein coding gene Chr4:76113832-76147587 (-)
CAST/EiJ MGP_CASTEiJ_G0027541
 protein coding gene Chr4:80756065-80787410 (-)
CBA/J MGP_CBAJ_G0028069
 protein coding gene Chr4:89005139-89038736 (-)
DBA/2J MGP_DBA2J_G0028218
 protein coding gene Chr4:79940974-79971748 (-)
FVB/NJ MGP_FVBNJ_G0028184
 protein coding gene Chr4:78954680-78985625 (-)
LP/J MGP_LPJ_G0028318
 protein coding gene Chr4:83420764-83454137 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028213
 protein coding gene Chr4:94088183-94120990 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028861
 protein coding gene Chr4:82304659-82335390 (-)
PWK/PhJ MGP_PWKPhJ_G0027264
 protein coding gene Chr4:78291625-78324248 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027089
 protein coding gene Chr4:79833514-79870873 (-)
WSB/EiJ MGP_WSBEiJ_G0027617
 protein coding gene Chr4:82469951-82501374 (-)



Homology
more
  • Human Ortholog
    PSIP1, PC4 and SRSF1 interacting protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSIP1, PC4 and SRSF1 interacting protein 1
  • Synonyms
    DFS70, LEDGF, p52, p75, PAIP, PSIP2
  • Links
    NCBI Gene ID: 11168
    neXtProt AC: NX_O75475
    UniProt: O75475

  • Chr Location
    9p22.3; chr9:15464066-15510995 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 3 alleles in 5 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene tend to die perinatally. Survivors show reduced fertility and a variety of skeletal and behavioral abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    783
  • Tissues
    25
  • cDNA Data
    20
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028484 Ensembl Gene Model | MGI Sequence Detail 30780 C57BL/6J ±  kb
    transcript ENSMUST00000030207 Ensembl | MGI Sequence Detail 3251 Not Applicable  
    polypeptide ENSMUSP00000030207 Ensembl | MGI Sequence Detail 528 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000003418 PC4 and SFRS1-interacting protein
      (term hierarchy)
    • InterPro Domains
      IPR036218 HIV integrase-binding domain superfamily
      IPR021567 Lens epithelium-derived growth factor, integrase-binding domain
      IPR000313 PWWP domain
      IPR035441 TFIIS/LEDGF domain superfamily
    • GlyGen
      Q99JF8 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 20
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2140137
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory