Strn4 MGI Mouse Gene Detail - MGI:2142346 - striatin, calmodulin binding protein 4

Symbol

Strn4
Name

striatin, calmodulin binding protein 4
Synonyms

ZIN, zinedin

Feature Type

protein coding gene
IDs

MGI:2142346
NCBI Gene: 97387
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr7:16549814-16574856 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 9.15 cM
Mapping Data

1 experiment

SNPs within 2kb

562 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2142346	protein coding gene	Chr7:16549814-16574856 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031718	protein coding gene	Chr7:14566286-14591604 (+)
A/J	MGP_AJ_G0031690	protein coding gene	Chr7:14295887-14320934 (+)
AKR/J	MGP_AKRJ_G0031615	protein coding gene	Chr7:14634044-14659065 (+)
BALB/cJ	MGP_BALBcJ_G0031697	protein coding gene	Chr7:14405136-14430168 (+)
C3H/HeJ	MGP_C3HHeJ_G0031419	protein coding gene	Chr7:14816014-14841859 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032163	protein coding gene	Chr7:15302789-15327820 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029242	protein coding gene	Chr7:15831774-15857060 (+)
CAST/EiJ	MGP_CASTEiJ_G0030770	protein coding gene	Chr7:11589385-11615139 (+)
CBA/J	MGP_CBAJ_G0031378	protein coding gene	Chr7:15797378-15822930 (+)
DBA/2J	MGP_DBA2J_G0031534	protein coding gene	Chr7:14185764-14211324 (+)
FVB/NJ	MGP_FVBNJ_G0031490	protein coding gene	Chr7:14084733-14111708 (+)
LP/J	MGP_LPJ_G0031619	protein coding gene	Chr7:14807141-14832453 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031525	protein coding gene	Chr7:15730101-15755143 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032192	protein coding gene	Chr7:14408177-14433200 (+)
PWK/PhJ	MGP_PWKPhJ_G0030494	protein coding gene	Chr7:11705038-11730578 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030321	protein coding gene	Chr7:9336448-9361470 (+)
WSB/EiJ	MGP_WSBEiJ_G0030867	protein coding gene	Chr7:14479263-14505876 (+)

Human Ortholog

STRN4, striatin 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STRN4, striatin 4
Synonyms

PPP2R6C, ZIN, zinedin
Links

HGNC:15721

NCBI Gene ID: 29888

neXtProt AC: NX_Q9NRL3

UniProt: Q9NRL3
Chr Location

19q13.32; chr19:46719511-46746994 (-) GRCh38

MGI Vertebrate Homology

Strn4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: STRN4
Gene Tree

Strn4

less

Phenotype Summary

11 phenotypes from 1 allele in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Gene trapped

2
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

31
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1157
Tissues

77
cDNA Data

151
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

82
RefSeq

12
UniProt

6
CCDS

CCDS39786.1, CCDS39787.1

Ensembl

ENSMUSG00000030374 (Evidence)
NCBI Gene

97387

			Length	Strain/Species	Flank
genomic	97387	NCBI Gene Model \| MGI Sequence Detail	25043	C57BL/6J	± kb
transcript	NM_133789	RefSeq \| MGI Sequence Detail	3562	C57BL/6
polypeptide	P58404	UniProt \| EBI \| MGI Sequence Detail	760	Not Applicable

less

UniProt

6 Sequences
Protein Ontology

PR:000015780 striatin-4

(term hierarchy)
InterPro Domains

IPR020472 G-protein beta WD-40 repeat

IPR013258 Striatin, N-terminal

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

IPR051488 WD repeat-containing striatin

less

All nucleic 151

cDNA 151

Microarray probesets 5

Summaries

All 36

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 8
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Strn4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr64628	Chr7:16550198-16550211 (+)	391 bp
Tssr64629	Chr7:16550224-16550286 (+)	441 bp
Tssr64630	Chr7:16564765-16564786 (+)	14,962 bp
Tssr64631	Chr7:16564787-16564796 (+)	14,978 bp
Tssr64632	Chr7:16564801-16564808 (+)	14,991 bp
Tssr64633	Chr7:16572049-16572066 (+)	22,244 bp
Tssr64634	Chr7:16572077-16572088 (+)	22,269 bp
Tssr64635	Chr7:16572101-16572118 (+)	22,296 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24