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Ces2a Gene Detail
Summary
  • Symbol
    Ces2a
  • Name
    carboxylesterase 2A
  • Synonyms
    9130231C15Rik, Ces6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142491
    NCBI Gene: 102022
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:105460635-105468266 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.04 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    321 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142491
 protein coding gene Chr8:105460635-105468266 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034018
 protein coding gene Chr8:106900017-106909506 (+)
A/J MGP_AJ_G0033999
 protein coding gene Chr8:102662086-102669925 (+)
AKR/J MGP_AKRJ_G0033925
 protein coding gene Chr8:105627592-105634700 (+)
BALB/cJ MGP_BALBcJ_G0033992
 protein coding gene Chr8:102864078-102872259 (+)
C3H/HeJ MGP_C3HHeJ_G0033704
 protein coding gene Chr8:106342138-106352535 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034512
 protein coding gene Chr8:110819033-110825927 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0033031
 protein coding gene Chr8:105885975-105901393 (+)
CBA/J MGP_CBAJ_G0033678
 protein coding gene Chr8:114505436-114506608 (+)
DBA/2J MGP_DBA2J_G0033832
 protein coding gene Chr8:102001834-102009473 (+)
FVB/NJ MGP_FVBNJ_G0033779
 protein coding gene Chr8:100940895-100951181 (+)
LP/J MGP_LPJ_G0033923
 protein coding gene Chr8:107080328-107096859 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033821
 protein coding gene Chr8:117666976-117677187 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034530
 protein coding gene Chr8:105570009-105581622 (+)
PWK/PhJ MGP_PWKPhJ_G0032733
 protein coding gene Chr8:101411802-101433626 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0033146
 protein coding gene Chr8:106268685-106281931 (+)



Homology
more
  • Human Ortholog
    CES2, carboxylesterase 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CES2, carboxylesterase 2
  • Synonyms
    CE-2, CES2A1, iCE, PCE-2
  • Links
    NCBI Gene ID: 8824
    neXtProt AC: NX_O00748
    UniProt: O00748

  • Chr Location
    16q22.1; chr16:66934444-66945096 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Knock-out mice are obese, with increased adiposity, and high-fat diet feeding exacerbates hepatic steatosis and impairs glucose homeostasis, with insulin resistance and glucose intolerance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    1
  • cDNA Data
    63
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 102022 NCBI Gene Model | MGI Sequence Detail 7632 C57BL/6J ±  kb
    transcript NM_133960 RefSeq | MGI Sequence Detail 1964 C57BL/6  
    polypeptide Q8QZR3 UniProt | EBI | MGI Sequence Detail 558 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 63
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 4
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:335459 Chalhoub G, et al., Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism. Mol Metab. 2023 Jun;72:101725
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory