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Plekhg4 Gene Detail
Summary
  • Symbol
    Plekhg4
  • Name
    pleckstrin homology domain containing, family G (with RhoGef domain) member 4
  • Synonyms
    4931414L13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142544
    NCBI Gene: 102075
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:106099906-106109494 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.04 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    300 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142544
 protein coding gene Chr8:106096272-106109494 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034043
 protein coding gene Chr8:107646211-107658256 (+)
A/J MGP_AJ_G0034024
 protein coding gene Chr8:103351799-103361387 (+)
AKR/J MGP_AKRJ_G0033950
 protein coding gene Chr8:106339826-106349414 (+)
BALB/cJ MGP_BALBcJ_G0034017
 protein coding gene Chr8:103529964-103539552 (+)
C3H/HeJ MGP_C3HHeJ_G0033729
 protein coding gene Chr8:107084788-107099165 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034537
 protein coding gene Chr8:111588921-111602102 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031479
 protein coding gene Chr8:96500492-96510093 (+)
CAST/EiJ MGP_CASTEiJ_G0033055
 protein coding gene Chr8:106586341-106595905 (+)
CBA/J MGP_CBAJ_G0033702
 protein coding gene Chr8:115204653-115216720 (+)
DBA/2J MGP_DBA2J_G0033857
 protein coding gene Chr8:102697805-102707393 (+)
FVB/NJ MGP_FVBNJ_G0033803
 protein coding gene Chr8:101621674-101631262 (+)
LP/J MGP_LPJ_G0033948
 protein coding gene Chr8:107857136-107866961 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033846
 protein coding gene Chr8:118406911-118416499 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034555
 protein coding gene Chr8:106314494-106324082 (+)
PWK/PhJ MGP_PWKPhJ_G0032756
 protein coding gene Chr8:102085024-102094626 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032597
 protein coding gene Chr8:104986904-104996515 (+)
WSB/EiJ MGP_WSBEiJ_G0033171
 protein coding gene Chr8:106967714-106977302 (+)



Homology
more
  • Human Ortholog
    PLEKHG4, pleckstrin homology and RhoGEF domain containing G4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLEKHG4, pleckstrin homology and RhoGEF domain containing G4
  • Synonyms
    ARHGEF44, PRTPHN1, SCA4
  • Links
    NCBI Gene ID: 25894
    neXtProt AC: NX_Q58EX7
    UniProt: Q58EX7

  • Chr Location
    16q22.1; chr16:67277510-67289499 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    9
  • cDNA Data
    8
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000014782 Ensembl Gene Model | MGI Sequence Detail 9589 C57BL/6J ±  kb
transcript ENSMUST00000214056 Ensembl | MGI Sequence Detail 3654 Not Applicable  
polypeptide ENSMUSP00000150574 Ensembl | MGI Sequence Detail 1217 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • InterPro Domains
    IPR000219 Dbl homology (DH) domain
    IPR035899 Dbl homology (DH) domain superfamily
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
    IPR052231 Rho GEF and signaling-related domain-containing protein
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 24
    Developmental Gene Expression 1
    Phenotypes 3
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:357979 Takenaka N, et al., Role of the guanine nucleotide exchange factor in Akt2-mediated plasma membrane translocation of GLUT4 in insulin-stimulated skeletal muscle. Cell Signal. 2014 Nov;26(11):2460-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory