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Mtus1 Gene Detail
Summary
  • Symbol
    Mtus1
  • Name
    mitochondrial tumor suppressor 1
  • Synonyms
    Atip1, B430305I03Rik, MD44, MTSG1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142572
    NCBI Gene: 102103
  • Alliance
    gene page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:41443951-41586763 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 23.89 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5028 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142572
 protein coding gene Chr8:41443949-41587318 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033559
 protein coding gene Chr8:39822935-39970742 (-)
A/J MGP_AJ_G0033542
 protein coding gene Chr8:38300974-38447295 (-)
AKR/J MGP_AKRJ_G0033465
 protein coding gene Chr8:39460222-39609276 (-)
BALB/cJ MGP_BALBcJ_G0033537
 protein coding gene Chr8:38421652-38568895 (-)
C3H/HeJ MGP_C3HHeJ_G0033247
 protein coding gene Chr8:39841692-39998830 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034053
 protein coding gene Chr8:41334490-41479876 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031002
 protein coding gene Chr8:34962394-35105231 (-)
CAST/EiJ MGP_CASTEiJ_G0032575
 protein coding gene Chr8:39349918-39498256 (-)
CBA/J MGP_CBAJ_G0033225
 protein coding gene Chr8:43043809-43196676 (-)
DBA/2J MGP_DBA2J_G0033379
 protein coding gene Chr8:38136813-38283650 (-)
FVB/NJ MGP_FVBNJ_G0033323
 protein coding gene Chr8:37720372-37865533 (-)
LP/J MGP_LPJ_G0033468
 protein coding gene Chr8:39864916-40009931 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033365
 protein coding gene Chr8:42799857-42958724 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034071
 protein coding gene Chr8:39613225-39767525 (-)
PWK/PhJ MGP_PWKPhJ_G0032284
 protein coding gene Chr8:37681290-37827288 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032116
 protein coding gene Chr8:38773067-38927851 (-)
WSB/EiJ MGP_WSBEiJ_G0032690
 protein coding gene Chr8:39823773-39969969 (-)



Homology
more
  • Human Ortholog
    MTUS1, microtubule associated scaffold protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTUS1, microtubule associated scaffold protein 1
  • Synonyms
    ATBP, ATIP, ATIP3, ICIS, MP44, MTSG1
  • Links
    NCBI Gene ID: 57509
    neXtProt AC: NX_Q9ULD2
    UniProt: Q9ULD2

  • Chr Location
    8p22; chr8:17643795-17801521 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit spontaneous heart hypertrophy and SLE-like lymphoproliferative disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1264
  • Tissues
    212
  • cDNA Data
    18
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045636 Ensembl Gene Model | MGI Sequence Detail 142813 C57BL/6J ±  kb
    transcript ENSMUST00000118835 Ensembl | MGI Sequence Detail 6426 Not Applicable  
    polypeptide ENSMUSP00000112626 Ensembl | MGI Sequence Detail 1210 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000010754 mitochondrial tumor suppressor 1
      (term hierarchy)
    • InterPro Domains
      IPR051293 Microtubule-associated tumor suppressor/Coiled-coil domain-containing protein 69
    • GlyGen
      Q5HZI1 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 21
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142870, MGI:2442464
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:253738 Wang Y, et al., MTUS1 silencing promotes E-selectin production through p38 MAPK-dependent CREB ubiquitination in endothelial cells. J Mol Cell Cardiol. 2016 Dec;101:1-10
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory