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Nek5 Gene Detail
Summary
  • Symbol
    Nek5
  • Name
    NIMA (never in mitosis gene a)-related expressed kinase 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142824
    NCBI Gene: 330721
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:22563632-22615069 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 10.95 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1942 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142824
 protein coding gene Chr8:22563631-22615443 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033444
 protein coding gene Chr8:19914126-19965581 (-)
A/J MGP_AJ_G0033424
 protein coding gene Chr8:19266970-19316558 (-)
AKR/J MGP_AKRJ_G0033349
 protein coding gene Chr8:19894231-19945383 (-)
BALB/cJ MGP_BALBcJ_G0033420
 protein coding gene Chr8:19387729-19442268 (-)
C3H/HeJ MGP_C3HHeJ_G0033134
 protein coding gene Chr8:20087874-20142013 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033936
 protein coding gene Chr8:20764385-20809783 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0032460
 protein coding gene Chr8:19513604-19567019 (-)
CBA/J MGP_CBAJ_G0033109
 protein coding gene Chr8:21591460-21638333 (-)
DBA/2J MGP_DBA2J_G0033264
 protein coding gene Chr8:19237685-19284397 (-)
FVB/NJ MGP_FVBNJ_G0033208
 protein coding gene Chr8:19033387-19084731 (-)
LP/J MGP_LPJ_G0033353
 protein coding gene Chr8:19916016-19961156 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033251
 protein coding gene Chr8:21187242-21245107 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033955
 protein coding gene Chr8:19793001-19844862 (-)
PWK/PhJ MGP_PWKPhJ_G0032172
 protein coding gene Chr8:18827399-18873289 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032005
 protein coding gene Chr8:19183886-19233585 (-)
WSB/EiJ MGP_WSBEiJ_G0032576
 protein coding gene Chr8:19989323-20048835 (-)



Homology
more
  • Human Ortholog
    NEK5, NIMA related kinase 5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEK5, NIMA related kinase 5
  • Links
    NCBI Gene ID: 341676
    neXtProt AC: NX_Q6P3R8
    UniProt: Q6P3R8

  • Chr Location
    13q14.3; chr13:52033611-52129092 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation exhibit progressive hearing impairment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    4
  • cDNA Data
    8
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037738 Ensembl Gene Model | MGI Sequence Detail 51438 C57BL/6J ±  kb
transcript ENSMUST00000209656 Ensembl | MGI Sequence Detail 2253 Not Applicable  
polypeptide ENSMUSP00000148211 Ensembl | MGI Sequence Detail 627 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 2
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 4
  • Earliest
    J:84167 Forrest AR, et al., Exploration of the cell-cycle genes found within the RIKEN FANTOM2 data set. Genome Res. 2003 Jun;13(6B):1366-75
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory