Lars2 MGI Mouse Gene Detail - MGI:2142973 - leucyl-tRNA synthetase, mitochondrial

Symbol

Lars2
Name

leucyl-tRNA synthetase, mitochondrial

Feature Type

protein coding gene
IDs

MGI:2142973
NCBI Gene: 102436
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr9:123196001-123291731 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 73.92 cM, cytoband F
Mapping Data

2 experiments

SNPs within 2kb

2617 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2142973	protein coding gene	Chr9:123195992-123291731 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035476	protein coding gene	Chr9:126404923-126508878 (+)
A/J	MGP_AJ_G0035457	protein coding gene	Chr9:121571107-121670200 (+)
AKR/J	MGP_AKRJ_G0035390	protein coding gene	Chr9:124829610-124926941 (+)
BALB/cJ	MGP_BALBcJ_G0035453	protein coding gene	Chr9:121492645-121603288 (+)
C3H/HeJ	MGP_C3HHeJ_G0035160	protein coding gene	Chr9:125276697-125376495 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035976	protein coding gene	Chr9:129905513-130007288 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032858	protein coding gene	Chr9:118699706-118793433 (+)
CAST/EiJ	MGP_CASTEiJ_G0034465	protein coding gene	Chr9:125309954-125412284 (+)
CBA/J	MGP_CBAJ_G0035128	protein coding gene	Chr9:134617277-134740421 (+)
DBA/2J	MGP_DBA2J_G0035287	protein coding gene	Chr9:121019159-121115391 (+)
FVB/NJ	MGP_FVBNJ_G0035234	protein coding gene	Chr9:119924645-120021138 (+)
LP/J	MGP_LPJ_G0035366	protein coding gene	Chr9:126746149-126845773 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035275	protein coding gene	Chr9:135454863-135553853 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035995	protein coding gene	Chr9:125295703-125390887 (+)
PWK/PhJ	MGP_PWKPhJ_G0034169	protein coding gene	Chr9:121465619-121565517 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034006	protein coding gene	Chr9:125403932-125510708 (+)
WSB/EiJ	MGP_WSBEiJ_G0034585	protein coding gene	Chr9:125139978-125235117 (+)

Human Ortholog

LARS2, leucyl-tRNA synthetase 2, mitochondrial

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LARS2, leucyl-tRNA synthetase 2, mitochondrial
Synonyms

HLASA, LEURS, mtLeuRS, PRLTS4
Links

HGNC:17095

NCBI Gene ID: 23395

neXtProt AC: NX_Q15031

UniProt: Q15031
Chr Location

3p21.31; chr3:45388561-45554726 (+) GRCh38

MGI Vertebrate Homology

Lars2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LARS2
Gene Tree

Lars2

Diseases

1 with human LARS2 associations

				Human Disease	Mouse Models
				Perrault syndrome IDs Perrault syndrome DOID:0050857 OMIM:233400 OMIM:614129 OMIM:614926 OMIM:615300 OMIM:PS233400 ORDO:2855

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotype references

All Mutations and Alleles

13
Endonuclease-mediated

2
Gene trapped

10
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

80 strains or lines available

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All GO Annotations

14
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

803
Tissues

96
cDNA Data

50
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lars2

ZFIN lars2

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All Sequences

69
RefSeq

6
UniProt

8
CCDS

CCDS23659.1

Ensembl

ENSMUSG00000035202 (Evidence)
NCBI Gene

102436

			Length	Strain/Species	Flank
genomic	102436	NCBI Gene Model \| MGI Sequence Detail	95731	C57BL/6J	± kb
transcript	NM_001348167	RefSeq \| MGI Sequence Detail	4219	ZRU/MplStud
polypeptide	Q8VDC0	UniProt \| EBI \| MGI Sequence Detail	902	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000032134 leucine--tRNA ligase, mitochondrial

(term hierarchy)
EC

6.1.1.4
InterPro Domains

IPR002300 Aminoacyl-tRNA synthetase, class Ia

IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding

IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site

IPR002302 Leucine-tRNA ligase

IPR025709 Leucyl-tRNA synthetase, editing domain

IPR015413 Methionyl/Leucyl tRNA synthetase

IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding

IPR014729 Rossmann-like alpha/beta/alpha sandwich fold

IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
GlyGen

Q8VDC0 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 52

cDNA 50

Primer pair 2

Microarray probesets 4

Summaries

All 42

Developmental Gene Expression 4

Gene Ontology 11

Phenotypes 9
Earliest

J:80594 Kiss H, et al., Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3. Mamm Genome. 2002 Nov;13(11):646-55
Latest

J:328989 Patel SD, et al., Deficiency of the bZIP transcription factors Mafg and Mafk causes misexpression of genes in distinct pathways and results in lens embryonic developmental defects. Front Cell Dev Biol. 2022;10:981893

TSS for Lars2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87907	Chr9:123195986-123196018 (+)	1 bp
Tssr87908	Chr9:123290961-123290975 (+)	94,967 bp
Tssr87909	Chr9:123290993-123291049 (+)	95,020 bp
Tssr87910	Chr9:123291058-123291065 (+)	95,061 bp
Tssr87911	Chr9:123291140-123291155 (+)	95,147 bp
Tssr87912	Chr9:123291161-123291168 (+)	95,164 bp
Tssr87913	Chr9:123291205-123291231 (+)	95,217 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24