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Dennd4a Gene Detail
Summary
  • Symbol
    Dennd4a
  • Name
    DENN domain containing 4A
  • Synonyms
    F730015K02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142979
    NCBI Gene: 102442
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:64718622-64826949 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 34.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2676 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142979
protein coding gene Chr9:64713408-64826949 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034944
protein coding gene Chr9:64494424-64613631 (+)
A/J MGP_AJ_G0034924
protein coding gene Chr9:62336274-62445198 (+)
AKR/J MGP_AKRJ_G0034854
protein coding gene Chr9:63794765-63907869 (+)
BALB/cJ MGP_BALBcJ_G0034917
protein coding gene Chr9:62060484-62169190 (+)
C3H/HeJ MGP_C3HHeJ_G0034627
protein coding gene Chr9:64323514-64435113 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035436
protein coding gene Chr9:66263327-66387140 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032347
protein coding gene Chr9:61974643-62086422 (+)
CAST/EiJ MGP_CASTEiJ_G0033948
protein coding gene Chr9:64491407-64607929 (+)
CBA/J MGP_CBAJ_G0034598
protein coding gene Chr9:68565511-68683315 (+)
DBA/2J MGP_DBA2J_G0034757
protein coding gene Chr9:62115506-62223030 (+)
FVB/NJ MGP_FVBNJ_G0034699
protein coding gene Chr9:61420143-61528593 (+)
LP/J MGP_LPJ_G0034840
protein coding gene Chr9:64784222-64894406 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034741
protein coding gene Chr9:69822858-69950853 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035458
protein coding gene Chr9:63908576-64021254 (+)
PWK/PhJ MGP_PWKPhJ_G0033652
protein coding gene Chr9:62282171-62394802 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033486
protein coding gene Chr9:64172832-64284067 (+)
WSB/EiJ MGP_WSBEiJ_G0034061
protein coding gene Chr9:63803045-63914824 (+)



Homology
more
  • Human Ortholog
    DENND4A, DENN domain containing 4A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DENND4A, DENN domain containing 4A
  • Synonyms
    IRLB, MYCPBP
  • Links
    NCBI Gene ID: 10260
    neXtProt AC: NX_Q7Z401
    UniProt: Q7Z401

  • Chr Location
    15q22.31; chr15:65658046-65792293 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053641 Ensembl Gene Model | MGI Sequence Detail 108328 C57BL/6J ±  kb
transcript ENSMUST00000038890 Ensembl | MGI Sequence Detail 8645 Not Applicable  
polypeptide ENSMUSP00000037915 Ensembl | MGI Sequence Detail 1869 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 62
    cDNA 62

    Microarray probesets 11
Other
Accession IDs
less
MGI:2143156, MGI:2442199
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 6
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory