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Pif1 Gene Detail
Summary
  • Symbol
    Pif1
  • Name
    PIF1 5'-to-3' DNA helicase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143057
    NCBI Gene: 208084
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:65494442-65503249 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 35.40 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    298 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2143057
 protein coding gene Chr9:65494432-65503249 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034963
 protein coding gene Chr9:65343688-65352348 (+)
A/J MGP_AJ_G0034943
 protein coding gene Chr9:63128451-63137073 (+)
AKR/J MGP_AKRJ_G0034873
 protein coding gene Chr9:64623772-64634849 (+)
BALB/cJ MGP_BALBcJ_G0034936
 protein coding gene Chr9:62850162-62859537 (+)
C3H/HeJ MGP_C3HHeJ_G0034646
 protein coding gene Chr9:65151052-65160288 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035455
 protein coding gene Chr9:67127234-67135762 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032366
 protein coding gene Chr9:62774586-62783160 (+)
CAST/EiJ MGP_CASTEiJ_G0033967
 protein coding gene Chr9:65332286-65341013 (+)
CBA/J MGP_CBAJ_G0034617
 protein coding gene Chr9:69465207-69477855 (+)
DBA/2J MGP_DBA2J_G0034776
 protein coding gene Chr9:62896690-62905233 (+)
FVB/NJ MGP_FVBNJ_G0034718
 protein coding gene Chr9:62221530-62231508 (+)
LP/J MGP_LPJ_G0034859
 protein coding gene Chr9:65604852-65614809 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034760
 protein coding gene Chr9:70681924-70691812 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035477
 protein coding gene Chr9:64725405-64733917 (+)
PWK/PhJ MGP_PWKPhJ_G0033671
 protein coding gene Chr9:63101391-63110227 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033505
 protein coding gene Chr9:65016587-65028651 (+)
WSB/EiJ MGP_WSBEiJ_G0034080
 protein coding gene Chr9:64631285-64641009 (+)



Homology
more
  • Human Ortholog
    PIF1, PIF1 5'-to-3' DNA helicase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIF1, PIF1 5'-to-3' DNA helicase
  • Synonyms
    C15orf20, PIF
  • Links
    NCBI Gene ID: 80119
    neXtProt AC: NX_Q9H611
    UniProt: Q9H611

  • Chr Location
    15q22.31; chr15:64815632-64827062 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and overtly normal and show no evidence of increased sensitivity to DNA damage, genetic instability, reproducible telomere length alteration or other cellular abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1058
  • Tissues
    36
  • cDNA Data
    23
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041064 Ensembl Gene Model | MGI Sequence Detail 8808 C57BL/6J ±  kb
transcript ENSMUST00000239405 Ensembl | MGI Sequence Detail 3680 Not Applicable  
polypeptide ENSMUSP00000159314 Ensembl | MGI Sequence Detail 650 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 23

    Microarray probesets 5
References
more
  • Summaries
    All 43
    Developmental Gene Expression 4
    Gene Ontology 11
    Phenotypes 11
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory