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Plekho2 Gene Detail
Summary
  • Symbol
    Plekho2
  • Name
    pleckstrin homology domain containing, family O member 2
  • Synonyms
    Plekhq1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143132
    NCBI Gene: 102595
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:65459980-65487322 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 35.38 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    725 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2143132
 protein coding gene Chr9:65459859-65487369 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034962
 protein coding gene Chr9:65302407-65330845 (-)
A/J MGP_AJ_G0034942
 protein coding gene Chr9:63094879-63120094 (-)
AKR/J MGP_AKRJ_G0034872
 protein coding gene Chr9:64583767-64608809 (-)
BALB/cJ MGP_BALBcJ_G0034935
 protein coding gene Chr9:62817261-62842421 (-)
C3H/HeJ MGP_C3HHeJ_G0034645
 protein coding gene Chr9:65114668-65142691 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035454
 protein coding gene Chr9:67080798-67114275 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032365
 protein coding gene Chr9:62743032-62767941 (-)
CAST/EiJ MGP_CASTEiJ_G0033966
 protein coding gene Chr9:65300275-65325915 (-)
CBA/J MGP_CBAJ_G0034616
 protein coding gene Chr9:69423452-69453858 (-)
DBA/2J MGP_DBA2J_G0034775
 protein coding gene Chr9:62863434-62889021 (-)
FVB/NJ MGP_FVBNJ_G0034717
 protein coding gene Chr9:62188444-62213756 (-)
LP/J MGP_LPJ_G0034858
 protein coding gene Chr9:65569620-65597097 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034759
 protein coding gene Chr9:70644953-70672453 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035476
 protein coding gene Chr9:64691442-64718014 (-)
PWK/PhJ MGP_PWKPhJ_G0033670
 protein coding gene Chr9:63068634-63093413 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033504
 protein coding gene Chr9:64974920-65003499 (-)
WSB/EiJ MGP_WSBEiJ_G0034079
 protein coding gene Chr9:64594770-64622818 (-)



Homology
more
  • Human Ortholog
    PLEKHO2, pleckstrin homology domain containing O2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLEKHO2, pleckstrin homology domain containing O2
  • Synonyms
    PLEKHQ1, PP1628, pp9099
  • Links
    NCBI Gene ID: 80301
    neXtProt AC: NX_Q8TD55
    UniProt: Q8TD55

  • Chr Location
    15q22.31; chr15:64841883-64868002 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced macrophages in the spleen, blood and peritoneal cavity due to increased apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    39
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050721 Ensembl Gene Model | MGI Sequence Detail 27343 C57BL/6J ±  kb
transcript ENSMUST00000068944 Ensembl | MGI Sequence Detail 3273 Not Applicable  
polypeptide ENSMUSP00000063677 Ensembl | MGI Sequence Detail 495 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000029681 pleckstrin homology domain-containing family O member 2
    (term hierarchy)
  • InterPro Domains
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
    IPR043448 Pleckstrin homology domain-containing family O member 1/2
  • GlyGen
    Q8K124 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 39
    cDNA 39

    Microarray probesets 3
References
more
  • Summaries
    All 27
    Gene Ontology 2
    Phenotypes 9
  • Earliest
    J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory