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Phldb1 Gene Detail
Summary
  • Symbol
    Phldb1
  • Name
    pleckstrin homology like domain, family B, member 1
  • Synonyms
    D330037A14Rik, LL5A, mKIAA0638
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143230
    NCBI Gene: 102693
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr9:44597601-44646495 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1281 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2143230
 protein coding gene Chr9:44597601-44649800 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034716
 protein coding gene Chr9:43210411-43259188 (-)
A/J MGP_AJ_G0034697
 protein coding gene Chr9:41989775-42040997 (-)
AKR/J MGP_AKRJ_G0034624
 protein coding gene Chr9:42863796-42912960 (-)
BALB/cJ MGP_BALBcJ_G0034688
 protein coding gene Chr9:41736289-41785146 (-)
C3H/HeJ MGP_C3HHeJ_G0034399
 protein coding gene Chr9:43316947-43366819 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035209
 protein coding gene Chr9:44485055-44537513 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032124
 protein coding gene Chr9:41560917-41610583 (-)
CAST/EiJ MGP_CASTEiJ_G0033721
 protein coding gene Chr9:43178878-43228502 (-)
CBA/J MGP_CBAJ_G0034371
 protein coding gene Chr9:46107267-46158777 (-)
DBA/2J MGP_DBA2J_G0034530
 protein coding gene Chr9:41893596-41942479 (-)
FVB/NJ MGP_FVBNJ_G0034471
 protein coding gene Chr9:41153718-41204172 (-)
LP/J MGP_LPJ_G0034611
 protein coding gene Chr9:43506809-43557026 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034515
 protein coding gene Chr9:47941254-47991154 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035230
 protein coding gene Chr9:42780677-42830331 (-)
PWK/PhJ MGP_PWKPhJ_G0033426
 protein coding gene Chr9:41778233-41827321 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033262
 protein coding gene Chr9:43088154-43136882 (-)
WSB/EiJ MGP_WSBEiJ_G0033834
 protein coding gene Chr9:42807507-42859125 (-)



Homology
more
  • Human Ortholog
    PHLDB1, pleckstrin homology like domain family B member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PHLDB1, pleckstrin homology like domain family B member 1
  • Synonyms
    LL5A, LL5alpha, OI23
  • Links
    NCBI Gene ID: 23187
    neXtProt AC: NX_Q86UU1
    UniProt: Q86UU1

  • Chr Location
    11q23.3; chr11:118606436-118658031 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PHLDB1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    94
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048537 Ensembl Gene Model | MGI Sequence Detail 48895 C57BL/6J ±  kb
    transcript ENSMUST00000138356 Ensembl | MGI Sequence Detail 5600 Not Applicable  
    polypeptide ENSMUSP00000120208 Ensembl | MGI Sequence Detail 1449 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      17 Sequences
    • Protein Ontology
      PR:000030919 pleckstrin homology-like domain family B member 1
      (term hierarchy)
    • InterPro Domains
      IPR000253 Forkhead-associated (FHA) domain
      IPR037810 PHLDB1/2/3, PH domain
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
      IPR052212 Pleckstrin homology-like domain-containing protein
      IPR008984 SMAD/FHA domain superfamily
    • GlyGen
      Q6PDH0 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 94
      cDNA 94

      Microarray probesets 4
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 8
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory