About   Help   FAQ
L3mbtl3 Gene Detail
Summary
  • Symbol
    L3mbtl3
  • Name
    L3MBTL3 histone methyl-lysine binding protein
  • Synonyms
    MBT-1, mKIAA1798
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143628
    NCBI Gene: 237339
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:26150366-26251967 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 13.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2802 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2143628
 protein coding gene Chr10:26150361-26252426 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017103
 protein coding gene Chr10:24320555-24432160 (-)
A/J MGP_AJ_G0017080
 protein coding gene Chr10:23578263-23680670 (-)
AKR/J MGP_AKRJ_G0017040
 protein coding gene Chr10:23973823-24080950 (-)
BALB/cJ MGP_BALBcJ_G0017043
 protein coding gene Chr10:23712131-23815209 (-)
C3H/HeJ MGP_C3HHeJ_G0016863
 protein coding gene Chr10:24185938-24291819 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017501
 protein coding gene Chr10:25080169-25189826 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015199
 protein coding gene Chr10:22239692-22338318 (-)
CAST/EiJ MGP_CASTEiJ_G0016442
 protein coding gene Chr10:24193730-24303069 (-)
CBA/J MGP_CBAJ_G0016837
 protein coding gene Chr10:26265141-26370364 (-)
DBA/2J MGP_DBA2J_G0016942
 protein coding gene Chr10:23313884-23418001 (-)
FVB/NJ MGP_FVBNJ_G0016937
 protein coding gene Chr10:23000868-23102881 (-)
LP/J MGP_LPJ_G0017019
 protein coding gene Chr10:24326382-24432582 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016967
 protein coding gene Chr10:26249362-26358055 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017537
 protein coding gene Chr10:23855923-23970710 (-)
PWK/PhJ MGP_PWKPhJ_G0016224
 protein coding gene Chr10:23119874-23225413 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016008
 protein coding gene Chr10:23676704-23791281 (-)
WSB/EiJ MGP_WSBEiJ_G0016505
 protein coding gene Chr10:23989699-24097343 (-)



Homology
more
  • Human Ortholog
    L3MBTL3, L3MBTL histone methyl-lysine binding protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    L3MBTL3, L3MBTL histone methyl-lysine binding protein 3
  • Synonyms
    MBT-1, MBT1
  • Links
    NCBI Gene ID: 84456
    neXtProt AC: NX_Q96JM7
    UniProt: Q96JM7

  • Chr Location
    6q23.1; chr6:130013699-130141449 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation die between E17.5 ? 19.5 due to disturbed erythropoiesis which result in anemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    14
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039089 Ensembl Gene Model | MGI Sequence Detail 101602 C57BL/6J ±  kb
    transcript ENSMUST00000174766 Ensembl | MGI Sequence Detail 3411 Not Applicable  
    polypeptide ENSMUSP00000133479 Ensembl | MGI Sequence Detail 883 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:346895 Guo P, et al., A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis. Elife. 2024 Feb 12;13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory