Enpp3 MGI Mouse Gene Detail - MGI:2143702 - ectonucleotide pyrophosphatase/phosphodiesterase 3

Symbol

Enpp3
Name

ectonucleotide pyrophosphatase/phosphodiesterase 3
Synonyms

CD203c, MGC:6548

Feature Type

protein coding gene
IDs

MGI:2143702
NCBI Gene: 209558
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:24649712-24712093 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 12.26 cM
Mapping Data

1 experiment

SNPs within 2kb

2206 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2143702	protein coding gene	Chr10:24648304-24718721 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017094	protein coding gene	Chr10:22766368-22836127 (-)
A/J	MGP_AJ_G0017071	protein coding gene	Chr10:22098761-22162951 (-)
AKR/J	MGP_AKRJ_G0017031	protein coding gene	Chr10:22464673-22530436 (-)
BALB/cJ	MGP_BALBcJ_G0017034	protein coding gene	Chr10:22190168-22252924 (-)
C3H/HeJ	MGP_C3HHeJ_G0016854	protein coding gene	Chr10:22674696-22740343 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017492	protein coding gene	Chr10:23469705-23539909 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015190	protein coding gene	Chr10:20785993-20850328 (-)
CAST/EiJ	MGP_CASTEiJ_G0016433	protein coding gene	Chr10:22610318-22677280 (-)
CBA/J	MGP_CBAJ_G0016828	protein coding gene	Chr10:24533132-24602309 (-)
DBA/2J	MGP_DBA2J_G0016933	protein coding gene	Chr10:21825898-21889951 (-)
FVB/NJ	MGP_FVBNJ_G0016928	protein coding gene	Chr10:21529891-21593020 (-)
LP/J	MGP_LPJ_G0017010	protein coding gene	Chr10:22756324-22823603 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016958	protein coding gene	Chr10:24636898-24717257 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017528	protein coding gene	Chr10:22320422-22385065 (-)
PWK/PhJ	MGP_PWKPhJ_G0016215	protein coding gene	Chr10:21604201-21679307 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015999	protein coding gene	Chr10:22126113-22201193 (-)
WSB/EiJ	MGP_WSBEiJ_G0016496	protein coding gene	Chr10:22438364-22512718 (-)

Human Ortholog

ENPP3, ectonucleotide pyrophosphatase/phosphodiesterase 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ENPP3, ectonucleotide pyrophosphatase/phosphodiesterase 3
Synonyms

B10, CD203c, NPP3, PD-IBETA, PDNP3
Links

HGNC:3358

NCBI Gene ID: 5169

neXtProt AC: NX_O14638

UniProt: O14638
Chr Location

6q23.2; chr6:131628442-131747418 (+) GRCh38

MGI Vertebrate Homology

Enpp3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ENPP3
Gene Tree

Enpp3

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

27
Targeted

3
Genomic Mutations

1 involving Enpp3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

93 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knockout allele exhibit increased numbers of basophils and mast cells with increased susceptibility to chronic allergic responses.

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All GO Annotations

44
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

803
Tissues

95
cDNA Data

70
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase enpp3

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All Sequences

62
RefSeq

2
UniProt

10
CCDS

CCDS23752.1

Ensembl

ENSMUSG00000019989 (Evidence)
NCBI Gene

209558

			Length	Strain/Species	Flank
genomic	209558	NCBI Gene Model \| MGI Sequence Detail	62382	C57BL/6J	± kb
transcript	NM_134005	RefSeq \| MGI Sequence Detail	2815	C57BL/6
polypeptide	Q6DYE8	UniProt \| EBI \| MGI Sequence Detail	874	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000001344 ectonucleotide pyrophosphatase/phosphodiesterase family member 3

(term hierarchy)
EC

3.1.4.1, 3.6.1.-, 3.6.1.9
InterPro Domains

IPR017850 Alkaline-phosphatase-like, core domain superfamily

IPR001604 DNA/RNA non-specific endonuclease

IPR044929 DNA/RNA non-specific endonuclease superfamily

IPR020821 Extracellular Endonuclease, subunit A

IPR044925 His-Me finger superfamily

IPR001212 Somatomedin B domain

IPR036024 Somatomedin B-like domain superfamily

IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
GlyGen

Q6DYE8 9 sites, 5 N-linked glycans (5 sites)

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All nucleic 72

cDNA 70

Primer pair 2

Microarray probesets 6

Summaries

All 49

Developmental Gene Expression 2

Gene Ontology 11

Phenotypes 15
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:349427 Mardjuki R, et al., Identification of the extracellular membrane protein ENPP3 as a major cGAMP hydrolase and innate immune checkpoint. Cell Rep. 2024 May 28;43(5):114209

TSS for Enpp3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr97083	Chr10:24712063-24712079 (-)	22 bp
Tssr97082	Chr10:24704603-24704606 (-)	7,488 bp
Tssr97081	Chr10:24689641-24689645 (-)	22,450 bp
Tssr97080	Chr10:24681908-24681945 (-)	30,166 bp
Tssr97079	Chr10:24663665-24663674 (-)	48,423 bp
Tssr97078	Chr10:24660898-24660943 (-)	51,172 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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