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Psme4 Gene Detail
Summary
  • Symbol
    Psme4
  • Name
    proteasome (prosome, macropain) activator subunit 4
  • Synonyms
    b2b1508Clo
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143994
    NCBI Gene: 103554
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:30721726-30830361 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 18.16 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2355 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2143994
 protein coding gene Chr11:30721726-30831150 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018116
 protein coding gene Chr11:28881928-28995021 (+)
A/J MGP_AJ_G0018089
 protein coding gene Chr11:27799302-27912634 (+)
AKR/J MGP_AKRJ_G0018053
 protein coding gene Chr11:28687264-28799161 (+)
BALB/cJ MGP_BALBcJ_G0018058
 protein coding gene Chr11:28007602-28118580 (+)
C3H/HeJ MGP_C3HHeJ_G0017871
 protein coding gene Chr11:28611124-28730792 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018509
 protein coding gene Chr11:29836367-29949804 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016166
 protein coding gene Chr11:26328972-26433970 (+)
CAST/EiJ MGP_CASTEiJ_G0017433
 protein coding gene Chr11:28705086-28820428 (+)
CBA/J MGP_CBAJ_G0017844
 protein coding gene Chr11:31273497-31398900 (+)
DBA/2J MGP_DBA2J_G0017954
 protein coding gene Chr11:27618217-27732200 (+)
FVB/NJ MGP_FVBNJ_G0017948
 protein coding gene Chr11:27415066-27525586 (+)
LP/J MGP_LPJ_G0018026
 protein coding gene Chr11:29125057-29240509 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017972
 protein coding gene Chr11:32323799-32453336 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018550
 protein coding gene Chr11:28782618-28894576 (+)
PWK/PhJ MGP_PWKPhJ_G0017215
 protein coding gene Chr11:27724039-27831353 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017009
 protein coding gene Chr11:28500843-28611498 (+)
WSB/EiJ MGP_WSBEiJ_G0017485
 protein coding gene Chr11:28470504-28585993 (+)



Homology
more
  • Human Ortholog
    PSME4, proteasome activator subunit 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSME4, proteasome activator subunit 4
  • Synonyms
    Blm10, hBlm10, PA200
  • Links
    NCBI Gene ID: 23198
    neXtProt AC: NX_Q14997
    UniProt: Q14997

  • Chr Location
    2p16.2; chr2:53864069-53970993 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Psme4 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 3 alleles in 3 genetic backgrounds
    27 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show normal repair of DNA double-strand breaks but exhibit significantly reduced male fertility due to defects in spermatogenesis observed in both meiotic spermatocytes and postmeiotic haploid spermatids.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    791
  • Tissues
    13
  • cDNA Data
    418
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040850 Ensembl Gene Model | MGI Sequence Detail 108636 C57BL/6J ±  kb
    transcript ENSMUST00000041231 Ensembl | MGI Sequence Detail 6491 Not Applicable  
    polypeptide ENSMUSP00000045460 Ensembl | MGI Sequence Detail 1843 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000013395 proteasome activator complex subunit 4
      (term hierarchy)
    • InterPro Domains
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR032430 Proteasome activator Blm10, mid region
      IPR035309 Proteasome activator complex subunit 4
      IPR021843 Proteasome activator complex subunit 4 C-terminal domain
    • GlyGen
      Q5SSW2 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 418
      cDNA 418

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2144428
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 5
      Phenotypes 17
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:353428 VerPlank JJ, et al., Knockout of PA200 improves proteasomal degradation and myelination in a proteotoxic neuropathy. Life Sci Alliance. 2024 Apr;7(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory