Xpo1 MGI Mouse Gene Detail - MGI:2144013

Symbol

Xpo1
Name

exportin 1
Synonyms

Crm1

Feature Type

protein coding gene
IDs

MGI:2144013
NCBI Gene: 103573
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:23206055-23248249 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 14.28 cM
Mapping Data

3 experiments

SNPs within 2kb

790 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2144013	protein coding gene	Chr11:23205768-23248250 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018085	protein coding gene	Chr11:20988899-21040056 (+)
A/J	MGP_AJ_G0018058	protein coding gene	Chr11:20180769-20222982 (+)
AKR/J	MGP_AKRJ_G0018022	protein coding gene	Chr11:20900645-20944352 (+)
BALB/cJ	MGP_BALBcJ_G0018026	protein coding gene	Chr11:20319892-20364158 (+)
C3H/HeJ	MGP_C3HHeJ_G0017840	protein coding gene	Chr11:20787201-20830466 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018478	protein coding gene	Chr11:21858243-21904674 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016136	protein coding gene	Chr11:19076566-19117739 (+)
CAST/EiJ	MGP_CASTEiJ_G0017401	protein coding gene	Chr11:20818977-20862926 (+)
CBA/J	MGP_CBAJ_G0017814	protein coding gene	Chr11:22810818-22858863 (+)
DBA/2J	MGP_DBA2J_G0017924	protein coding gene	Chr11:20111015-20153426 (+)
FVB/NJ	MGP_FVBNJ_G0017916	protein coding gene	Chr11:19888115-19932048 (+)
LP/J	MGP_LPJ_G0017995	protein coding gene	Chr11:21101244-21143409 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017942	protein coding gene	Chr11:23290150-23336135 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018519	protein coding gene	Chr11:21011664-21053689 (+)
PWK/PhJ	MGP_PWKPhJ_G0017182	protein coding gene	Chr11:20151098-20193482 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016979	protein coding gene	Chr11:20769214-20810187 (+)
WSB/EiJ	MGP_WSBEiJ_G0017455	protein coding gene	Chr11:20647531-20691122 (+)

Human Ortholog

XPO1, exportin 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

XPO1, exportin 1
Synonyms

CRM-1, CRM1, emb, exp1
Links

HGNC:12825

NCBI Gene ID: 7514

neXtProt AC: NX_O14980

UniProt: O14980
Chr Location

2p15; chr2:61476032-61538741 (-) GRCh38

MGI Vertebrate Homology

Xpo1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: XPO1
Gene Tree

Xpo1

Diseases

4 with human XPO1 associations

				Human Disease	Mouse Models
				colorectal cancer IDs colorectal cancer DOID:9256 ICD10CM:C18.9 KEGG:05210 MESH:D015179 NCI:C2956 NCI:C4978 OMIM:114500 UMLS_CUI:C0009404 UMLS_CUI:C0346629
				gastric adenocarcinoma IDs gastric adenocarcinoma DOID:3717 NCI:C4004 UMLS_CUI:C0278701
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

80
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

74
Targeted

2
Genomic Mutations

1 involving Xpo1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

89 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

61
GO References

32

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

857
Tissues

125
cDNA Data

232
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase xpo1

ZFIN xpo1a, xpo1b

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All Sequences

68
RefSeq

10
UniProt

5
CCDS

CCDS24475.1

Ensembl

ENSMUSG00000020290 (Evidence)
NCBI Gene

103573

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020290	Ensembl Gene Model \| MGI Sequence Detail	42195	C57BL/6J	± kb
transcript	ENSMUST00000102870	Ensembl \| MGI Sequence Detail	3471	Not Applicable
polypeptide	ENSMUSP00000099934	Ensembl \| MGI Sequence Detail	1071	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000017497 exportin-1

(term hierarchy)
PDB

3GJX, 3NBY, 3NBZ, 3NC0, 3NC1
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR041123 Chromosome region maintenance repeat

IPR045065 Exportin-1/5

IPR014877 Exportin-1, C-terminal

IPR013598 Exportin-1/Importin-beta-like

IPR041235 Exportin-1, repeat 2

IPR040485 Exportin-1, repeat 3

IPR001494 Importin-beta, N-terminal domain
GlyGen

Q6P5F9 1 site, 1 O-linked glycan (1 site)

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All nucleic 236

cDNA 232

Primer pair 3

Other 1

Microarray probesets 6

Summaries

All 97

Developmental Gene Expression 8

Gene Ontology 32

Phenotypes 16
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Xpo1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100612	Chr11:23205920-23205976 (+)	-107 bp
Tssr100613	Chr11:23205980-23206000 (+)	-65 bp
Tssr100614	Chr11:23206001-23206105 (+)	-2 bp
Tssr100615	Chr11:23206566-23206580 (+)	518 bp
Tssr100616	Chr11:23207456-23207464 (+)	1,405 bp
Tssr100617	Chr11:23219613-23219620 (+)	13,562 bp
Tssr100618	Chr11:23234303-23234320 (+)	28,257 bp
Tssr100619	Chr11:23234655-23234669 (+)	28,607 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24