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Ppp4r3b Gene Detail
Summary
  • Symbol
    Ppp4r3b
  • Name
    protein phosphatase 4 regulatory subunit 3B
  • Synonyms
    mKIAA1387, Smek2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144474
    NCBI Gene: 104570
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:29122890-29170797 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 16.46 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    826 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144474
protein coding gene Chr11:29118053-29170797 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018104
protein coding gene Chr11:27165612-27218156 (+)
A/J MGP_AJ_G0018076
protein coding gene Chr11:26177028-26226095 (+)
AKR/J MGP_AKRJ_G0018041
protein coding gene Chr11:27025367-27075174 (+)
BALB/cJ MGP_BALBcJ_G0018044
protein coding gene Chr11:26365325-26417341 (+)
C3H/HeJ MGP_C3HHeJ_G0017858
protein coding gene Chr11:26935802-26983724 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018497
protein coding gene Chr11:28136697-28184752 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016154
protein coding gene Chr11:24823024-24870238 (+)
CAST/EiJ MGP_CASTEiJ_G0017420
protein coding gene Chr11:26975171-27032605 (+)
CBA/J MGP_CBAJ_G0017832
protein coding gene Chr11:29427250-29487201 (+)
DBA/2J MGP_DBA2J_G0017942
protein coding gene Chr11:26030020-26080252 (+)
FVB/NJ MGP_FVBNJ_G0017934
protein coding gene Chr11:25833732-25882200 (+)
LP/J MGP_LPJ_G0018014
protein coding gene Chr11:27418944-27470154 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017960
protein coding gene Chr11:30491690-30547958 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018537
protein coding gene Chr11:27131422-27183007 (+)
PWK/PhJ MGP_PWKPhJ_G0017202
protein coding gene Chr11:26123533-26173302 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016997
protein coding gene Chr11:26810506-26860521 (+)
WSB/EiJ MGP_WSBEiJ_G0017473
protein coding gene Chr11:26820606-26872689 (+)



Homology
more
  • Human Ortholog
    PPP4R3B, protein phosphatase 4 regulatory subunit 3B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP4R3B, protein phosphatase 4 regulatory subunit 3B
  • Synonyms
    FLFL2, PP4R3B, PSY2, SMEK2, smk1
  • Links
    NCBI Gene ID: 57223
    neXtProt AC: NX_Q5MIZ7
    UniProt: Q5MIZ7

  • Chr Location
    2p16.1; chr2:55547292-55618880 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020463 Ensembl Gene Model | MGI Sequence Detail 47908 C57BL/6J ±  kb
    transcript ENSMUST00000020755 Ensembl | MGI Sequence Detail 5125 Not Applicable  
    polypeptide ENSMUSP00000020755 Ensembl | MGI Sequence Detail 820 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000015282 serine/threonine-protein phosphatase 4 regulatory subunit 3B
    • InterPro Domains
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR011993 PH-like domain superfamily
      IPR051137 Serine/threonine-protein phosphatase 4 regulatory subunit 3
      IPR006887 Serine/threonine-protein phosphatase 4 regulatory subunit 3-like, central domain
    • GlyGen
      Q922R5 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 2
      cDNA 25

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2144578
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    12/17/2024
    MGI 6.24
    The Jackson Laboratory