Alkbh5 MGI Mouse Gene Detail - MGI:2144489 - alkB homolog 5, RNA demethylase

Symbol

Alkbh5
Name

alkB homolog 5, RNA demethylase
Synonyms

Abh5, Ofoxd

Feature Type

protein coding gene
IDs

MGI:2144489
NCBI Gene: 268420
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:60428509-60449338 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 37.81 cM
Mapping Data

2 experiments

SNPs within 2kb

348 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2144489	protein coding gene	Chr11:60427207-60449338 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018420	protein coding gene	Chr11:60422550-60444570 (+)
A/J	MGP_AJ_G0018389	protein coding gene	Chr11:58126273-58148582 (+)
AKR/J	MGP_AKRJ_G0018359	protein coding gene	Chr11:60073497-60098505 (+)
BALB/cJ	MGP_BALBcJ_G0018360	protein coding gene	Chr11:58482533-58504840 (+)
C3H/HeJ	MGP_C3HHeJ_G0018173	protein coding gene	Chr11:59944077-59967214 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018812	protein coding gene	Chr11:62331083-62353255 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016458	protein coding gene	Chr11:55363585-55385008 (+)
CAST/EiJ	MGP_CASTEiJ_G0017730	protein coding gene	Chr11:60085379-60107287 (+)
CBA/J	MGP_CBAJ_G0018147	protein coding gene	Chr11:65067149-65089471 (+)
DBA/2J	MGP_DBA2J_G0018256	protein coding gene	Chr11:57781341-57803447 (+)
FVB/NJ	MGP_FVBNJ_G0018247	protein coding gene	Chr11:57462082-57483986 (+)
LP/J	MGP_LPJ_G0018329	protein coding gene	Chr11:61026349-61049164 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018271	protein coding gene	Chr11:66114424-66136556 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018853	protein coding gene	Chr11:60095940-60117832 (+)
PWK/PhJ	MGP_PWKPhJ_G0017501	protein coding gene	Chr11:58391323-58414076 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017293	protein coding gene	Chr11:59895591-59917673 (+)
WSB/EiJ	MGP_WSBEiJ_G0017781	protein coding gene	Chr11:59778913-59802870 (+)

Human Ortholog

ALKBH5, alkB homolog 5, RNA demethylase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ALKBH5, alkB homolog 5, RNA demethylase
Synonyms

ABH5, OFOXD, OFOXD1
Links

HGNC:25996

NCBI Gene ID: 54890

neXtProt AC: NX_Q6P6C2

UniProt: Q6P6C2
Chr Location

17p11.2; chr17:18183078-18209954 (+) GRCh38

MGI Vertebrate Homology

Alkbh5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ALKBH5
Gene Tree

Alkbh5

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References

2 with disease annotations

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

8
Gene trapped

2
Targeted

3
Genomic Mutations

3 involving Alkbh5
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced male fertility associated with oligo- and teratozoopermia and male germ cell apoptosis.

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All GO Annotations

40
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

726
Tissues

4
cDNA Data

13
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase alkbh5

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All Sequences

48
RefSeq

2
UniProt

1
CCDS

CCDS24794.1

Ensembl

ENSMUSG00000042650 (Evidence)
NCBI Gene

268420

			Length	Strain/Species	Flank
genomic	268420	NCBI Gene Model \| MGI Sequence Detail	20830	C57BL/6J	± kb
transcript	NM_172943	RefSeq \| MGI Sequence Detail	6025	Not Specified
polypeptide	Q3TSG4	UniProt \| EBI \| MGI Sequence Detail	395	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000003952 alkylated DNA repair protein alkB 5

(term hierarchy)
EC

1.14.11.53
InterPro Domains

IPR027450 Alpha-ketoglutarate-dependent dioxygenase AlkB-like

IPR037151 Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily

IPR032860 RNA demethylase ALKBH5

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All nucleic 16

Genomic 1

cDNA 13

Primer pair 2

Microarray probesets 7

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MGI:2144515

Summaries

All 62

Developmental Gene Expression 4

Diseases 2

Gene Ontology 11

Phenotypes 29
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:355331 Mao Y, et al., Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance. J Neuroinflammation. 2024 Oct 4;21(1):249

TSS for Alkbh5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101896	Chr11:60427413-60427450 (+)	-1,077 bp
Tssr101897	Chr11:60428487-60428564 (+)	17 bp
Tssr101898	Chr11:60428788-60428810 (+)	290 bp
Tssr101899	Chr11:60428815-60428900 (+)	349 bp
Tssr101900	Chr11:60428930-60428942 (+)	427 bp
Tssr101901	Chr11:60430550-60430555 (+)	2,044 bp
Tssr101902	Chr11:60432196-60432200 (+)	3,689 bp
Tssr101903	Chr11:60444572-60444603 (+)	16,079 bp
Tssr101904	Chr11:60445771-60445786 (+)	17,270 bp
Tssr101905	Chr11:60448720-60448729 (+)	20,216 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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