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Ddx1 Gene Detail
Summary
  • Symbol
    Ddx1
  • Name
    DEAD box helicase 1
  • Synonyms
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144727
    NCBI Gene: 104721
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:13269308-13299175 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 6.40 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    856 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144727
 protein coding gene Chr12:13266974-13299214 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019605
 protein coding gene Chr12:10477912-10507011 (-)
A/J MGP_AJ_G0019571
 protein coding gene Chr12:10128277-10156132 (-)
AKR/J MGP_AKRJ_G0019542
 protein coding gene Chr12:10734485-10764255 (-)
BALB/cJ MGP_BALBcJ_G0019548
 protein coding gene Chr12:10317515-10345382 (-)
C3H/HeJ MGP_C3HHeJ_G0019353
 protein coding gene Chr12:10566379-10594351 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019996
 protein coding gene Chr12:10848484-10876589 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017622
 protein coding gene Chr12:9803935-9831854 (-)
CAST/EiJ MGP_CASTEiJ_G0018908
 protein coding gene Chr12:10452915-10481522 (-)
CBA/J MGP_CBAJ_G0019324
 protein coding gene Chr12:11549149-11577147 (-)
DBA/2J MGP_DBA2J_G0019437
 protein coding gene Chr12:10088958-10117188 (-)
FVB/NJ MGP_FVBNJ_G0019428
 protein coding gene Chr12:9996135-10023988 (-)
LP/J MGP_LPJ_G0019508
 protein coding gene Chr12:10595082-10625213 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019462
 protein coding gene Chr12:11323682-11352224 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020035
 protein coding gene Chr12:10368445-10396483 (-)
PWK/PhJ MGP_PWKPhJ_G0018674
 protein coding gene Chr12:10157461-10185678 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018464
 protein coding gene Chr12:10496493-10524717 (-)
WSB/EiJ MGP_WSBEiJ_G0018959
 protein coding gene Chr12:10465730-10494909 (-)



Homology
more
  • Human Ortholog
    DDX1, DEAD-box helicase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDX1, DEAD-box helicase 1
  • Synonyms
    DBP-RB, UKVH5d
  • Links
    NCBI Gene ID: 1653
    neXtProt AC: NX_Q92499
    UniProt: Q92499

  • Chr Location
    2p24.3; chr2:15591178-15634346 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    756
  • Tissues
    25
  • cDNA Data
    181
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 104721 NCBI Gene Model | MGI Sequence Detail 29868 C57BL/6J ±  kb
transcript NM_134040 RefSeq | MGI Sequence Detail 2488 FVB/N  
polypeptide Q91VR5 UniProt | EBI | MGI Sequence Detail 740 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 183
    cDNA 181
    Primer pair 1
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 52
    Developmental Gene Expression 7
    Gene Ontology 10
    Phenotypes 16
  • Earliest
    J:81851 Fowles LF, et al., Genomic screen for genes involved in mammalian craniofacial development. Genesis. 2003 Feb;35(2):73-87
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory