Lrfn5 MGI Mouse Gene Detail - MGI:2144814 - leucine rich repeat and fibronectin type III domain containing 5

Symbol

Lrfn5
Name

leucine rich repeat and fibronectin type III domain containing 5

Feature Type

protein coding gene
IDs

MGI:2144814
NCBI Gene: 238205
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr12:61569936-61905128 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 26.43 cM
Mapping Data

2 experiments

SNPs within 2kb

10217 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2144814	protein coding gene	Chr12:61569356-61913554 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019772	protein coding gene	Chr12:60859887-61222918 (+)
A/J	MGP_AJ_G0019731	protein coding gene	Chr12:58644846-58966173 (+)
AKR/J	MGP_AKRJ_G0019706	protein coding gene	Chr12:60476952-60818962 (+)
BALB/cJ	MGP_BALBcJ_G0019711	protein coding gene	Chr12:59034463-59360226 (+)
C3H/HeJ	MGP_C3HHeJ_G0019516	protein coding gene	Chr12:60680895-61025276 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020163	protein coding gene	Chr12:62669969-63032893 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017783	protein coding gene	Chr12:56792662-57103059 (+)
CAST/EiJ	MGP_CASTEiJ_G0019068	protein coding gene	Chr12:55502425-55860453 (+)
CBA/J	MGP_CBAJ_G0019485	protein coding gene	Chr12:65015422-65390513 (+)
DBA/2J	MGP_DBA2J_G0019601	protein coding gene	Chr12:58569489-58910892 (+)
FVB/NJ	MGP_FVBNJ_G0019589	protein coding gene	Chr12:57727608-58051167 (+)
LP/J	MGP_LPJ_G0019673	protein coding gene	Chr12:60906093-61244269 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019627	protein coding gene	Chr12:66960201-67417347 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020197	protein coding gene	Chr12:59892228-60238009 (+)
PWK/PhJ	MGP_PWKPhJ_G0018834	protein coding gene	Chr12:52831870-53169354 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018628	protein coding gene	Chr12:54285260-54623671 (+)
WSB/EiJ	MGP_WSBEiJ_G0019119	protein coding gene	Chr12:60451222-60787027 (+)

Human Ortholog

LRFN5, leucine rich repeat and fibronectin type III domain containing 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRFN5, leucine rich repeat and fibronectin type III domain containing 5
Synonyms

C14orf146, FIGLER8, SALM5
Links

HGNC:20360

NCBI Gene ID: 145581

neXtProt AC: NX_Q96NI6

UniProt: Q96NI6
Chr Location

14q21.1; chr14:41606876-41904549 (+) GRCh38

MGI Vertebrate Homology

Lrfn5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: LRFN5
Gene Tree

Lrfn5

less

Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

4
Genomic Mutations

1 involving Lrfn5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

20
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

891
Tissues

92
cDNA Data

12
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lrfn5

ZFIN lrfn5a, lrfn5b

less

All Sequences

55
RefSeq

13
UniProt

1
CCDS

CCDS25936.1, CCDS79117.1

Ensembl

ENSMUSG00000035653 (Evidence)
NCBI Gene

238205

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035653	Ensembl Gene Model \| MGI Sequence Detail	335193	C57BL/6J	± kb
transcript	ENSMUST00000055815	Ensembl \| MGI Sequence Detail	4410	Not Applicable
polypeptide	ENSMUSP00000051546	Ensembl \| MGI Sequence Detail	746	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000032376 leucine-rich repeat and fibronectin type-III domain-containing protein 5

(term hierarchy)
PDB

6F2O
InterPro Domains

IPR036116 Fibronectin type III superfamily

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR001611 Leucine-rich repeat

IPR050467 Leucine-rich repeat and fibronectin type-III domain-containing

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype
GlyGen

Q8BXA0 7 sites, 8 N-linked glycans (5 sites), 1 O-linked glycan (1 site)

less

All nucleic 15

cDNA 12

Primer pair 1

Other 2

Microarray probesets 5

less

MGI:2144863

Summaries

All 43

Developmental Gene Expression 10

Gene Ontology 8

Phenotypes 7
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:335585 Noack F, et al., Multimodal profiling of the transcriptional regulatory landscape of the developing mouse cortex identifies Neurog2 as a key epigenome remodeler. Nat Neurosci. 2022 Feb;25(2):154-167

TSS for Lrfn5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113573	Chr12:61569898-61569970 (+)	-2 bp
Tssr113574	Chr12:61570646-61570666 (+)	720 bp
Tssr113575	Chr12:61570675-61570708 (+)	756 bp
Tssr113576	Chr12:61571322-61571340 (+)	1,395 bp
Tssr113577	Chr12:61571386-61571426 (+)	1,470 bp
Tssr113578	Chr12:61575464-61575469 (+)	5,531 bp
Tssr113579	Chr12:61581009-61581012 (+)	11,075 bp
Tssr113580	Chr12:61618227-61618230 (+)	48,293 bp
Tssr113581	Chr12:61632973-61632990 (+)	63,046 bp
Tssr113582	Chr12:61650666-61650669 (+)	80,732 bp
Tssr113583	Chr12:61657246-61657257 (+)	87,316 bp
Tssr113584	Chr12:61678521-61678527 (+)	108,588 bp
Tssr113585	Chr12:61745746-61745750 (+)	175,812 bp
Tssr113586	Chr12:61763328-61763330 (+)	193,393 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24