Ptpn23 MGI Mouse Gene Detail - MGI:2144837 - protein tyrosine phosphatase, non-receptor type 23

Symbol

Ptpn23
Name

protein tyrosine phosphatase, non-receptor type 23
Synonyms

PTP-TD14

Feature Type

protein coding gene
IDs

MGI:2144837
NCBI Gene: 104831
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr9:110214152-110237278 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 59.92 cM
Mapping Data

1 experiment

SNPs within 2kb

594 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2144837	protein coding gene	Chr9:110214150-110237281 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035346	protein coding gene	Chr9:112530520-112553525 (-)
A/J	MGP_AJ_G0035327	protein coding gene	Chr9:108442460-108465344 (-)
AKR/J	MGP_AKRJ_G0035258	protein coding gene	Chr9:111135615-111160377 (-)
BALB/cJ	MGP_BALBcJ_G0035322	protein coding gene	Chr9:108187706-108212990 (-)
C3H/HeJ	MGP_C3HHeJ_G0035030	protein coding gene	Chr9:111639867-111663394 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035844	protein coding gene	Chr9:115583240-115606267 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032730	protein coding gene	Chr9:105664290-105687522 (-)
CAST/EiJ	MGP_CASTEiJ_G0034336	protein coding gene	Chr9:111426209-111450951 (-)
CBA/J	MGP_CBAJ_G0034997	protein coding gene	Chr9:119890301-119913286 (-)
DBA/2J	MGP_DBA2J_G0035156	protein coding gene	Chr9:107904385-107927441 (-)
FVB/NJ	MGP_FVBNJ_G0035103	protein coding gene	Chr9:106728522-106751730 (-)
LP/J	MGP_LPJ_G0035235	protein coding gene	Chr9:112826282-112849661 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035143	protein coding gene	Chr9:121244521-121269640 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035864	protein coding gene	Chr9:111462554-111486593 (-)
PWK/PhJ	MGP_PWKPhJ_G0034043	protein coding gene	Chr9:108146750-108170230 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033878	protein coding gene	Chr9:111554810-111579584 (-)
WSB/EiJ	MGP_WSBEiJ_G0034457	protein coding gene	Chr9:111341157-111364221 (-)

Human Ortholog

PTPN23, protein tyrosine phosphatase non-receptor type 23

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTPN23, protein tyrosine phosphatase non-receptor type 23
Synonyms

HD-PTP, HDPTP, NEDBASS, PTP-TD14
Links

HGNC:14406

NCBI Gene ID: 25930

neXtProt AC: NX_Q9H3S7

UniProt: Q9H3S7
Chr Location

3p21.31; chr3:47381011-47413435 (+) GRCh38

MGI Vertebrate Homology

Ptpn23 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PTPN23
Gene Tree

Ptpn23

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

3
Gene trapped

8
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

59 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Embryos homozygous for a gene trap allele are significantly growth retarded and fail to reach the E8.5 stage.

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All GO Annotations

46
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

822
Tissues

78
cDNA Data

57
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ptpn23

ZFIN ptpn23a, ptpn23b

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All Sequences

47
RefSeq

6
UniProt

2
CCDS

CCDS40780.1

Ensembl

ENSMUSG00000036057 (Evidence)
NCBI Gene

104831

			Length	Strain/Species	Flank
genomic	104831	NCBI Gene Model \| MGI Sequence Detail	23127	C57BL/6J	± kb
transcript	NM_001081043	RefSeq \| MGI Sequence Detail	5384	C57BL/6
polypeptide	Q6PB44	UniProt \| EBI \| MGI Sequence Detail	1692	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013458 tyrosine-protein phosphatase non-receptor type 23

(term hierarchy)
PDB

2W10
EC

3.1.3.48
InterPro Domains

IPR025304 ALIX V-shaped domain

IPR004328 BRO1 domain

IPR038499 BRO1 domain superfamily

IPR050348 Protein-Tyrosine Phosphatase

IPR016130 Protein-tyrosine phosphatase, active site

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR000242 Tyrosine-specific protein phosphatase, PTPase domain

IPR000387 Tyrosine-specific protein phosphatases domain

IPR045251 Vacuolar protein-sorting protein Bro1-like
GlyGen

Q6PB44 11 sites, 1 O-linked glycan (11 sites)

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All nucleic 60

cDNA 58

Primer pair 1

Other 1

Microarray probesets 3

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 15
Earliest

J:77230 Tanaka K, et al., Spermatogonia-dependent expression of testicular genes in mice. Dev Biol. 2002 Jun 15;246(2):466-79
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ptpn23:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr91613	Chr9:110237291-110237302 (-)	-19 bp
Tssr91612	Chr9:110237276-110237285 (-)	-3 bp
Tssr91611	Chr9:110237228-110237272 (-)	28 bp
Tssr91610	Chr9:110237199-110237223 (-)	67 bp
Tssr91609	Chr9:110217419-110217431 (-)	19,853 bp
Tssr91608	Chr9:110217295-110217311 (-)	19,975 bp
Tssr91607	Chr9:110217271-110217290 (-)	19,997 bp
Tssr91606	Chr9:110217152-110217170 (-)	20,117 bp
Tssr91605	Chr9:110216776-110216797 (-)	20,491 bp
Tssr91604	Chr9:110216709-110216729 (-)	20,559 bp
Tssr91603	Chr9:110216653-110216664 (-)	20,619 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24