Trib2 MGI Mouse Gene Detail - MGI:2145021

Symbol

Trib2
Name

tribbles pseudokinase 2
Synonyms

TRB2

Feature Type

protein coding gene
IDs

MGI:2145021
NCBI Gene: 217410
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr12:15841728-15866923 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 7.25 cM
Mapping Data

2 experiments

SNPs within 2kb

610 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2145021	protein coding gene	Chr12:15841726-15866963 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019608	protein coding gene	Chr12:13136614-13163180 (-)
A/J	MGP_AJ_G0019575	protein coding gene	Chr12:12697601-12722787 (-)
AKR/J	MGP_AKRJ_G0019545	protein coding gene	Chr12:13337102-13362287 (-)
BALB/cJ	MGP_BALBcJ_G0019551	protein coding gene	Chr12:12942540-12967724 (-)
C3H/HeJ	MGP_C3HHeJ_G0019356	protein coding gene	Chr12:13230891-13256104 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019999	protein coding gene	Chr12:13609811-13634962 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017625	protein coding gene	Chr12:12214240-12241974 (-)
CAST/EiJ	MGP_CASTEiJ_G0018911	protein coding gene	Chr12:13098406-13123555 (-)
CBA/J	MGP_CBAJ_G0019327	protein coding gene	Chr12:14382292-14407459 (-)
DBA/2J	MGP_DBA2J_G0019440	protein coding gene	Chr12:12621533-12646963 (-)
FVB/NJ	MGP_FVBNJ_G0019431	protein coding gene	Chr12:12485092-12510781 (-)
LP/J	MGP_LPJ_G0019511	protein coding gene	Chr12:13266078-13291310 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019466	protein coding gene	Chr12:14294732-14319917 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020038	protein coding gene	Chr12:12982210-13007841 (-)
PWK/PhJ	MGP_PWKPhJ_G0018677	protein coding gene	Chr12:12647273-12672793 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018467	protein coding gene	Chr12:13219036-13245769 (-)
WSB/EiJ	MGP_WSBEiJ_G0018962	protein coding gene	Chr12:13110165-13136518 (-)

Human Ortholog

TRIB2, tribbles pseudokinase 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRIB2, tribbles pseudokinase 2
Synonyms

C5FW, GS3955, TRB2
Links

HGNC:30809

NCBI Gene ID: 28951

neXtProt AC: NX_Q92519

UniProt: Q92519
Chr Location

2p24.3; chr2:12716910-12742734 (+) GRCh38

MGI Vertebrate Homology

Trib2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TRIB2
Gene Tree

Trib2

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

10 phenotypes from 4 alleles in 4 genetic backgrounds
24 phenotypes from multigenic genotypes
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Gene trapped

1
Targeted

8
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit nitrituria. Female homozygotes display decreased circulating triglyceride levels.

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All GO Annotations

19
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

969
Tissues

188
cDNA Data

103
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trib2

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All Sequences

50
RefSeq

6
UniProt

3
CCDS

CCDS25821.1

Ensembl

ENSMUSG00000020601 (Evidence)
NCBI Gene

217410

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020601	Ensembl Gene Model \| MGI Sequence Detail	25196	C57BL/6J	± kb
transcript	ENSMUST00000020922	Ensembl \| MGI Sequence Detail	4198	Not Applicable
polypeptide	ENSMUSP00000020922	Ensembl \| MGI Sequence Detail	343	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016639 tribbles homolog 2

(term hierarchy)
InterPro Domains

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR024104 Pseudokinase tribbles family/serine-threonine-protein kinase 40

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All nucleic 107

cDNA 103

Primer pair 3

Other 1

Microarray probesets 4

Summaries

All 76

Developmental Gene Expression 9

Diseases 1

Gene Ontology 8

Phenotypes 35
Earliest

J:92208 Takasato M, et al., Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice. Mech Dev. 2004 Jun;121(6):547-57
Latest

J:350286 Wirth S, et al., Astrocytic uptake of posttranslationally modified amyloid-beta leads to endolysosomal system disruption and induction of pro-inflammatory signaling. Glia. 2024 Aug;72(8):1451-1468

TSS for Trib2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr115797	Chr12:15866763-15866882 (-)	100 bp
Tssr115796	Chr12:15866737-15866748 (-)	180 bp
Tssr115795	Chr12:15866596-15866608 (-)	321 bp
Tssr115794	Chr12:15866172-15866191 (-)	741 bp
Tssr115793	Chr12:15866139-15866150 (-)	778 bp
Tssr115792	Chr12:15866031-15866060 (-)	877 bp
Tssr115791	Chr12:15866012-15866021 (-)	906 bp
Tssr115790	Chr12:15865971-15866007 (-)	934 bp
Tssr115789	Chr12:15865597-15865614 (-)	1,317 bp
Tssr115788	Chr12:15865573-15865584 (-)	1,344 bp
Tssr115787	Chr12:15864740-15864753 (-)	2,176 bp
Tssr115786	Chr12:15843170-15843174 (-)	23,751 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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