Cog5 MGI Mouse Gene Detail - MGI:2145130 - component of oligomeric golgi complex 5

Symbol

Cog5
Name

component of oligomeric golgi complex 5
Synonyms

5430405C01Rik, GOLTC1, GTC90

Feature Type

protein coding gene
IDs

MGI:2145130
NCBI Gene: 238123
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr12:31704868-31987629 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 13.68 cM
Mapping Data

2 experiments

SNPs within 2kb

6506 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2145130	protein coding gene	Chr12:31704848-31987629 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019665	protein coding gene	Chr12:29620447-29922046 (+)
A/J	MGP_AJ_G0019632	protein coding gene	Chr12:28774861-29067186 (+)
AKR/J	MGP_AKRJ_G0019603	protein coding gene	Chr12:29697127-29990911 (+)
BALB/cJ	MGP_BALBcJ_G0019609	protein coding gene	Chr12:28999978-29290716 (+)
C3H/HeJ	MGP_C3HHeJ_G0019413	protein coding gene	Chr12:29566947-29866594 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020056	protein coding gene	Chr12:30546605-30851460 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017681	protein coding gene	Chr12:28063765-28356619 (+)
CAST/EiJ	MGP_CASTEiJ_G0018968	protein coding gene	Chr12:24566839-24862540 (+)
CBA/J	MGP_CBAJ_G0019385	protein coding gene	Chr12:31531891-31844800 (+)
DBA/2J	MGP_DBA2J_G0019498	protein coding gene	Chr12:28607531-28890056 (+)
FVB/NJ	MGP_FVBNJ_G0019489	protein coding gene	Chr12:28401412-28685675 (+)
LP/J	MGP_LPJ_G0019568	protein coding gene	Chr12:29713655-30013811 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019524	protein coding gene	Chr12:31168753-31487313 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020096	protein coding gene	Chr12:29225698-29521126 (+)
PWK/PhJ	MGP_PWKPhJ_G0018735	protein coding gene	Chr12:23338947-23632480 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018523	protein coding gene	Chr12:23810304-24105668 (+)
WSB/EiJ	MGP_WSBEiJ_G0019018	protein coding gene	Chr12:29457507-29756727 (+)

Human Ortholog

COG5, component of oligomeric golgi complex 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COG5, component of oligomeric golgi complex 5
Synonyms

CDG2I, GOLTC1, GTC90
Links

HGNC:14857

NCBI Gene ID: 10466

neXtProt AC: NX_Q9UP83

UniProt: Q9UP83
Chr Location

7q22.3; chr7:107201372-107564261 (-) GRCh38

MGI Vertebrate Homology

Cog5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: COG5
Gene Tree

Cog5

Diseases

1 with human COG5 associations

				Human Disease	Mouse Models
				congenital disorder of glycosylation type IIi IDs congenital disorder of glycosylation type IIi DOID:0070261 OMIM:613612 ORDO:263487

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

74
Endonuclease-mediated

2
Gene trapped

72
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

139 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

17
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

58

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cog5

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All Sequences

57
RefSeq

12
UniProt

3
CCDS

CCDS49046.1

Ensembl

ENSMUSG00000035933 (Evidence)
NCBI Gene

238123

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035933	Ensembl Gene Model \| MGI Sequence Detail	282762	C57BL/6J	± kb
transcript	ENSMUST00000036862	Ensembl \| MGI Sequence Detail	2997	Not Applicable
polypeptide	ENSMUSP00000044797	Ensembl \| MGI Sequence Detail	829	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005688 conserved oligomeric Golgi complex subunit 5

(term hierarchy)
InterPro Domains

IPR019465 Conserved oligomeric Golgi complex subunit 5

IPR048485 Conserved oligomeric Golgi complex subunit 5, helical domain

IPR049176 Conserved oligomeric Golgi complex subunit 5, N-terminal

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All nucleic 58

cDNA 58

Microarray probesets 6

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MGI:2145129

Summaries

All 38

Gene Ontology 6

Phenotypes 10
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cog5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113120	Chr12:31704847-31704890 (+)	1 bp
Tssr113121	Chr12:31720999-31721004 (+)	16,134 bp
Tssr113122	Chr12:31785690-31785713 (+)	80,834 bp
Tssr113123	Chr12:31920581-31920585 (+)	215,715 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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