Pelo MGI Mouse Gene Detail - MGI:2145154 - pelota mRNA surveillance and ribosome rescue factor

Symbol

Pelo
Name

pelota mRNA surveillance and ribosome rescue factor

Feature Type

protein coding gene
IDs

MGI:2145154
NCBI Gene: 105083
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr13:115224891-115226694 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 64.61 cM
Mapping Data

3 experiments

SNPs within 2kb

168 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2145154	protein coding gene	Chr13:115224891-115226722 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020960	protein coding gene	Chr13:117852826-117856246 (-)
A/J	MGP_AJ_G0020910	protein coding gene	Chr13:113063122-113064955 (-)
AKR/J	MGP_AKRJ_G0020885	protein coding gene	Chr13:116457700-116459530 (-)
BALB/cJ	MGP_BALBcJ_G0020910	protein coding gene	Chr13:113783362-113785444 (-)
C3H/HeJ	MGP_C3HHeJ_G0020699	protein coding gene	Chr13:116293988-116296377 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021346	protein coding gene	Chr13:121281736-121283554 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018915	protein coding gene	Chr13:108328754-108330590 (-)
CAST/EiJ	MGP_CASTEiJ_G0020218	protein coding gene	Chr13:115974725-115978015 (-)
CBA/J	MGP_CBAJ_G0020661	protein coding gene	Chr13:125923055-125927050 (-)
DBA/2J	MGP_DBA2J_G0020784	protein coding gene	Chr13:112771586-112773462 (-)
FVB/NJ	MGP_FVBNJ_G0020768	protein coding gene	Chr13:111418985-111420818 (-)
LP/J	MGP_LPJ_G0020860	protein coding gene	Chr13:117836072-117837901 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020796	protein coding gene	Chr13:126180580-126182844 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021382	protein coding gene	Chr13:115959039-115960875 (-)
PWK/PhJ	MGP_PWKPhJ_G0019971	protein coding gene	Chr13:111566138-111568044 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019793	protein coding gene	Chr13:112282954-112284791 (-)
WSB/EiJ	MGP_WSBEiJ_G0020276	protein coding gene	Chr13:116592484-116594321 (-)

Human Ortholog

PELO, pelota mRNA surveillance and ribosome rescue factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PELO, pelota mRNA surveillance and ribosome rescue factor
Synonyms

CGI-17, PRO1770
Links

HGNC:8829

NCBI Gene ID: 53918

neXtProt AC: NX_Q9BRX2

UniProt: Q9BRX2
Chr Location

5q11.2; chr5:52787916-52804044 (+) GRCh38

MGI Vertebrate Homology

Pelo stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PELO
Gene Tree

Pelo

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Phenotype Summary

26 phenotypes from 4 alleles in 6 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit early embryonic lethality associated with embryonic growth retardation, aneuploidy, polyploidy, and developmental failure past E7.5 due to defects in cell proliferation.

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All GO Annotations

34
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

905
Tissues

117
cDNA Data

34
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pelo

ZFIN pelo

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All Sequences

41
RefSeq

2
UniProt

2
CCDS

CCDS26788.1

Ensembl

ENSMUSG00000042275 (Evidence)
NCBI Gene

105083

			Length	Strain/Species	Flank
genomic	105083	NCBI Gene Model \| MGI Sequence Detail	1804	C57BL/6J	± kb
transcript	NM_134058	RefSeq \| MGI Sequence Detail	1588	C57BL/6
polypeptide	Q80X73	UniProt \| EBI \| MGI Sequence Detail	385	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012541 protein pelota

(term hierarchy)
InterPro Domains

IPR005140 eRF1 domain 1/Pelota-like

IPR005141 eRF1 domain 2

IPR042226 eRF1, domain 2 superfamily

IPR005142 eRF1 domain 3

IPR038069 Pelota/DOM34, N-terminal domain

IPR029064 Ribosomal protein eL30-like superfamily

IPR004405 Translation release factor pelota

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All nucleic 36

cDNA 34

Primer pair 1

Other 1

Microarray probesets 2

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MGI:2145307

Summaries

All 38

Developmental Gene Expression 6

Gene Ontology 9

Phenotypes 9
Earliest

J:79789 Shamsadin R, et al., Mouse pelota gene (Pelo): cDNA cloning, genomic structure, and chromosomal localization. Cytogenet Genome Res. 2002;97(1-2):95-9
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Pelo:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124149	Chr13:115226659-115226777 (-)	-24 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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