Cdk20 MGI Mouse Gene Detail - MGI:2145349 - cyclin dependent kinase 20

Symbol

Cdk20
Name

cyclin dependent kinase 20
Synonyms

4932702G04Rik, Ccrk

Feature Type

protein coding gene
IDs

MGI:2145349
NCBI Gene: 105278
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr13:64580133-64587536 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 33.26 cM
Mapping Data

2 experiments

SNPs within 2kb

379 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2145349	protein coding gene	Chr13:64580128-64589587 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020679	protein coding gene	Chr13:64457415-64464436 (+)
A/J	MGP_AJ_G0020633	protein coding gene	Chr13:62120323-62127789 (+)
AKR/J	MGP_AKRJ_G0020610	protein coding gene	Chr13:64175381-64183811 (+)
BALB/cJ	MGP_BALBcJ_G0020631	protein coding gene	Chr13:62547388-62554422 (+)
C3H/HeJ	MGP_C3HHeJ_G0020426	protein coding gene	Chr13:63698238-63705309 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021067	protein coding gene	Chr13:66532740-66540864 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018643	protein coding gene	Chr13:59772658-59779628 (+)
CAST/EiJ	MGP_CASTEiJ_G0019943	protein coding gene	Chr13:63721482-63731036 (+)
CBA/J	MGP_CBAJ_G0020386	protein coding gene	Chr13:69090436-69101112 (+)
DBA/2J	MGP_DBA2J_G0020511	protein coding gene	Chr13:61958270-61965741 (+)
FVB/NJ	MGP_FVBNJ_G0020490	protein coding gene	Chr13:61057972-61065915 (+)
LP/J	MGP_LPJ_G0020585	protein coding gene	Chr13:64745951-64752998 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020519	protein coding gene	Chr13:68037008-68044164 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021109	protein coding gene	Chr13:63498248-63505809 (+)
PWK/PhJ	MGP_PWKPhJ_G0019697	protein coding gene	Chr13:61521284-61528419 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019523	protein coding gene	Chr13:61664594-61671622 (+)
WSB/EiJ	MGP_WSBEiJ_G0020003	protein coding gene	Chr13:63980153-63987146 (+)

Human Ortholog

CDK20, cyclin dependent kinase 20

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDK20, cyclin dependent kinase 20
Synonyms

CCRK, CDCH, P42, PNQALRE
Links

HGNC:21420

NCBI Gene ID: 23552

neXtProt AC: NX_Q8IZL9

UniProt: Q8IZL9
Chr Location

9q22.1; chr9:87966441-87974753 (-) GRCh38

MGI Vertebrate Homology

Cdk20 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDK20
Gene Tree

Cdk20

Diseases

1 with human CDK20 associations

				Human Disease	Mouse Models
				alcohol dependence IDs alcohol dependence DOID:0050741 KEGG:05034 OMIM:103780

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

22 phenotypes from 3 alleles in 3 genetic backgrounds
5 phenotypes from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

3
Genomic Mutations

1 involving Cdk20
Incidental Mutations

APF
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display exencephaly, open neural tubes, cleft palate, absence of the floor plate, achondroplasia of the radius and ulna, and abnormal cilia.

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All GO Annotations

28
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

3
cDNA Data

38
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN cdk20

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All Sequences

62
RefSeq

8
UniProt

6
CCDS

CCDS26601.1

Ensembl

ENSMUSG00000021483 (Evidence)
NCBI Gene

105278

			Length	Strain/Species	Flank
genomic	105278	NCBI Gene Model \| MGI Sequence Detail	7404	C57BL/6J	± kb
transcript	NM_053180	RefSeq \| MGI Sequence Detail	1854	Not Specified
polypeptide	Q9JHU3	UniProt \| EBI \| MGI Sequence Detail	346	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000005145 cyclin-dependent kinase 20

(term hierarchy)
EC

2.7.11.22
InterPro Domains

IPR050108 Cyclin-dependent kinase

IPR048002 Cyclin-dependent kinase 20-like, catalytic domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 38

cDNA 38

Microarray probesets 4

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MGI:2145459

Summaries

All 45

Developmental Gene Expression 4

Gene Ontology 11

Phenotypes 11
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:354284 Chaya T, et al., Ccrk-Mak/Ick signaling is a ciliary transport regulator essential for retinal photoreceptor survival. Life Sci Alliance. 2024 Nov;7(11)

TSS for Cdk20:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120217	Chr13:64580161-64580233 (+)	64 bp
Tssr120218	Chr13:64580293-64580371 (+)	199 bp
Tssr120219	Chr13:64580409-64580423 (+)	283 bp
Tssr120220	Chr13:64580577-64580593 (+)	452 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24