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Exoc5 Gene Detail
Summary
  • Symbol
    Exoc5
  • Name
    exocyst complex component 5
  • Synonyms
    PRO1912, SEC10, Sec10l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145645
    NCBI Gene: 105504
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:49249379-49304124 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 25.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1001 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2145645
 protein coding gene Chr14:49241547-49304124 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021228
 protein coding gene Chr14:42906448-42967388 (-)
A/J MGP_AJ_G0021177
 protein coding gene Chr14:41555993-41608456 (-)
AKR/J MGP_AKRJ_G0021155
 protein coding gene Chr14:43177940-43232104 (-)
BALB/cJ MGP_BALBcJ_G0021180
 protein coding gene Chr14:41604520-41656656 (-)
C3H/HeJ MGP_C3HHeJ_G0020963
 protein coding gene Chr14:42958764-43012319 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021615
 protein coding gene Chr14:44665209-44725157 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019174
 protein coding gene Chr14:40857032-40909876 (-)
CAST/EiJ MGP_CASTEiJ_G0020489
 protein coding gene Chr14:40096227-40156312 (-)
CBA/J MGP_CBAJ_G0020930
 protein coding gene Chr14:46105372-46163748 (-)
DBA/2J MGP_DBA2J_G0021053
 protein coding gene Chr14:41428068-41481171 (-)
FVB/NJ MGP_FVBNJ_G0021038
 protein coding gene Chr14:41170526-41225607 (-)
LP/J MGP_LPJ_G0021122
 protein coding gene Chr14:43156518-43220852 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021063
 protein coding gene Chr14:45403185-45484865 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021648
 protein coding gene Chr14:42711081-42764738 (-)
PWK/PhJ MGP_PWKPhJ_G0020237
 protein coding gene Chr14:38331190-38386392 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020062
 protein coding gene Chr14:38820837-38880531 (-)
WSB/EiJ MGP_WSBEiJ_G0020545
 protein coding gene Chr14:42815151-42870134 (-)



Homology
more
  • Human Ortholog
    EXOC5, exocyst complex component 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EXOC5, exocyst complex component 5
  • Synonyms
    HSEC10, PRO1912, SEC10, SEC10L1, SEC10P
  • Links
    NCBI Gene ID: 10640
    neXtProt AC: NX_O00471
    UniProt: O00471

  • Chr Location
    14q22.3; chr14:57200507-57268905 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Exoc5 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in all cells die prior to E8.5. Mice homozygous for a conditional allele activated in kidney cells exhibit ureteropelvic junction obstructions leading to neontal death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    6
  • cDNA Data
    16
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 105504 NCBI Gene Model | MGI Sequence Detail 54746 C57BL/6J ±  kb
    transcript NM_207214 RefSeq | MGI Sequence Detail 4659 C57BL/6  
    polypeptide Q3TPX4 UniProt | EBI | MGI Sequence Detail 708 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000007252 exocyst complex component 5
      (term hierarchy)
    • InterPro Domains
      IPR009976 Exocyst complex component Sec10-like
      IPR048627 Exocyst complex component Sec10-like, alpha-helical bundle
      IPR048625 Exocyst complex component Sec10, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2145643, MGI:2684922
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 10
      Phenotypes 18
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:357575 Wu H, et al., Oocyte-specific EXOC5 expression is required for mouse oogenesis and folliculogenesis. Mol Hum Reprod. 2024 Aug 5;30(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/05/2024
    MGI 6.24     		The Jackson Laboratory